ArticleSleep2015
A novel pathway for sensory-mediated arousal involves splicing of an intron in the period clock gene.
Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- A lipid-binding protein that boosts daytime wake is mainly located at the body surface and blocks light-induced lipid peroxidation in the brain.Current biology : CB · 2026Article
- DAYWAKE implicates novel roles for circulating lipid-binding proteins as extracerebral regulators of daytime wake-sleep behavior.FEBS letters · 2024Article
- A thermometer circuit for hot temperature adjusts Drosophila behavior to persistent heat.Current biology : CB · 2022Article
- Article
- Daywake, an Anti-siesta Gene Linked to a Splicing-Based Thermostat from an Adjoining Clock Gene.Current biology : CB · 2019Article
- Parallel clinal variation in the mid-day siesta of Drosophila melanogaster implicates continent-specific targets of natural selection.PLoS genetics · 2018Article
- The SR protein B52/SRp55 regulates splicing of the period thermosensitive intron and mid-day siesta in Drosophila.Scientific reports · 2018Article
- The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature.International journal of molecular sciences · 2017Review
- Posttranscriptional mechanisms controlling diurnal gene expression cycles by body temperature rhythms.RNA biology · 2017Review
- A Longer Siesta? DN1s in Control!Neuroscience bulletin · 2017Article
- Mid-day siesta in natural populations of D. melanogaster from Africa exhibits an altitudinal cline and is regulated by splicing of a thermosensitive intron in the period clock gene.BMC evolutionary biology · 2017Article
- Regulation of sleep plasticity by a thermo-sensitive circuit in Drosophila.Scientific reports · 2017Article
- Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp.Genes & development · 2016Article
- Article
- Reorganization of Sleep by Temperature in Drosophila Requires Light, the Homeostat, and the Circadian Clock.Current biology : CB · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesD. melanogaster is an excellent animal model to study how the circadian (≅24-h) timing system and sleep regulate daily wake-sleep cycles. Splicing of a temperature-sensitive 3'-terminal intron (termed dmpi8) from the circadian clock gene period (per) regulates the distribution of daily activity in Drosophila. The role of dmpi8 splicing on daily behavior was further evaluated by analyzing sleep.
designTransgenic flies of the same genetic background but expressing either a wild-type recombinant per gene or one where the efficiency of dmpi8 splicing was increased were exposed to different temperatures in daily light-dark cycles and sleep parameters measured. In addition, transgenic flies were briefly exposed to a variety of sensory-mediated stimuli to measure arousal responses.
resultsSurprisingly, we show that the effect of dmpi8 splicing on daytime activity levels does not involve a circadian role for per but is linked to adjustments in sensory-dependent arousal and sleep behavior. Genetically altered flies with high dmpi8 splicing efficiency remain aroused longer following short treatments with light and non-photic cues such as mechanical stimulation.
conclusionsWe propose that the thermal regulation of dmpi8 splicing acts as a temperature-calibrated rheostat in a novel arousal mechanism, so that on warm days the inefficient splicing of the dmpi8 intron triggers an increase in quiescence by decreasing sensory-mediated arousal, thus ensuring flies minimize being active during the hot midday sun despite the presence of light in the environment, which is usually a strong arousal cue for diurnal animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.