Evidence map›Paper›PMID 25325253›Full record

ArticleNutrients2014

A psycho-genetic study of hedonic responsiveness in relation to "food addiction".

Caroline Davis, Natalie J Loxton

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Questioning the validity of food addiction: a critical review.Frontiers in behavioral neuroscience · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Current Intervention Treatments for Food Addiction: A Systematic Review.Behavioral sciences (Basel, Switzerland) · 2021
    Review
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Caroline DavisSchool of Kinesiology & Health Sciences, 343 Bethune College, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada. cdavis@yorku.ca.
Natalie J LoxtonSchool of Applied Psychology, Griffith University, 176 Messines Ridge Road Mt Gravatt, Queensland 4122, Australia. n.loxton@griffith.edu.au.
Griffith University · AUYork University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While food addiction has no formally-recognized definition, it is typically operationalized according to the diagnostic principles established by the Yale Food Addiction Scale-an inventory based on the symptom criteria for substance dependence in the DSM-IV. Currently, there is little biologically-based research investigating the risk factors for food addiction. What does exist has focused almost exclusively on dopaminergic reward pathways in the brain. While brain opioid signaling has also been strongly implicated in the control of food intake, there is no research examining this neural circuitry in the association with food addiction. The purpose of the study was therefore to test a model predicting that a stronger activation potential of opioid circuitry-as indicated by the functional A118G marker of the mu-opioid receptor gene-would serve as an indirect risk factor for food addiction via a heightened hedonic responsiveness to palatable food. Results confirmed these relationships. In addition, our findings that the food-addiction group had significantly higher levels of hedonic responsiveness to food suggests that this bio-behavioral trait may foster a proneness to overeating, to episodes of binge eating, and ultimately to a compulsive and addictive pattern of food intake.

Indexed as

FoodAdultBehavior, AddictiveEatingFeeding BehaviorFemaleHumansMaleMiddle AgedNerve NetReceptors, Opioid, muReceptors, Opioid, mu

Identifiers

PMID25325253
PMCPMC4210920
OpenAlexW2123842995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.