Evidence map›Paper›PMID 25325252›Full record

ArticleNutrients2014

Cod liver oil supplement consumption and health: cross-sectional results from the EPIC-Norfolk cohort study.

Marleen A H Lentjes, Ailsa A Welch, Angela A Mulligan, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw

Abstract read
In one paragraph

Article in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Functional food: complementary to fight against COVID-19.Beni-Suef University journal of basic and applied sciences · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marleen A H LentjesDepartment of Public Health and Primary Care, Strangeways Research Laboratories, University of Cambridge, 2 Worts Causeway, Cambridge CB1 8RN, UK. marleen.lentjes@phpc.cam.ac.uk.
Ailsa A WelchDepartment of Population Health and Primary Care, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK. a.welch@uea.ac.uk.
Angela A MulliganDepartment of Public Health and Primary Care, Strangeways Research Laboratories, University of Cambridge, 2 Worts Causeway, Cambridge CB1 8RN, UK. angela.mulligan@phpc.cam.ac.uk.
Robert N LubenDepartment of Public Health and Primary Care, Strangeways Research Laboratories, University of Cambridge, 2 Worts Causeway, Cambridge CB1 8RN, UK. robert.luben@phpc.cam.ac.uk.
Nicholas J WarehamMedical Research Council, Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. nick.wareham@mrc-epid.cam.ac.uk.
Kay-Tee KhawClinical Gerontology Unit, School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. kk101@medschl.cam.ac.uk.

Funding

Cancer Research UK SP2024-0201Cancer Research UK SP2024-0204Medical Research Council G0401527Medical Research Council G1000143Medical Research Council G9502233Medical Research Council MC_U106179471Medical Research Council MC_UU_12015/1
6 · The paper itself

Abstract

Supplement users (SU) make healthy lifestyle choices; on the other hand, SU report more medical conditions. We hypothesised that cod liver oil (CLO) consumers are similar to non-supplement users, since CLO use might originate from historical motives, i.e., rickets prevention, and not health consciousness. CLO consumers were studied in order to identify possible confounders, such as confounding by indication. The European Prospective Investigation into Cancer (EPIC) investigates causes of chronic disease. The participants were 25,639 men and women, aged 40-79 years, recruited from general practices in Norfolk, East-Anglia (UK). Participants completed questionnaires and a health examination between 1993 and 1998. Supplement use was measured using 7-day diet diaries. CLO was the most common supplement used, more prevalent among women and associated with not smoking, higher physical activity level and more favourable eating habits. SU had a higher occurrence of benign growths and bone-related diseases, but CLO was negatively associated with cardiovascular-related conditions. Although the results of SU characteristics in EPIC-Norfolk are comparable with studies worldwide, the CLO group is different from SU in general. Confounding by indication takes place and will need to be taken into account when analysing prospective associations of CLO use with fracture risk and cardiovascular diseases.

Indexed as

Feeding BehaviorAgedAge FactorsCod Liver OilCohort StudiesConfounding Factors, EpidemiologicCross-Sectional StudiesDietary SupplementsDiet SurveysFemaleHumansLife StyleMaleMiddle AgedMotor ActivitySex FactorsCod Liver Oil

Identifiers

PMID25325252
PMCPMC4210919

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.