ArticleFrontiers in bioengineering and biotechnology2014
Impact of Amorphous SiO2 Nanoparticles on a Living Organism: Morphological, Behavioral, and Molecular Biology Implications.
Article in Frontiers in bioengineering and biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- Facile and cost-effective synthesis and characterization of hormone stabilized biocompatible gold nanoparticles for biomedical applications.Scientific reports · 2026Article
- Terminal sialic acids in the nanoparticle corona modulate cellular uptake.Communications chemistry · 2025Article
- Toxicity of fluorescent silica nanoparticles in brine shrimp and their implications as food ingestion markers.Scientific reports · 2025Article
- Article
- Characterization and Behaviour of Silica Engineered Nanocontainers in Low and High Ionic Strength Media.Nanomaterials (Basel, Switzerland) · 2023Article
- Sensitivity ofToxics · 2022Article
- Metal(loid) nanosorbents in restoration of polluted soils: geochemical, ecotoxicological, and remediation perspectives.Environmental geochemistry and health · 2022Review
- Proposing Urothelial and Muscle In Vitro Cell Models as a Novel Approach for Assessment of Long-Term Toxicity of Nanoparticles.International journal of molecular sciences · 2020Article
- A simple and rapid method for toxicity evaluation of zinc oxide nanoparticle (ZnO NPs) in benthic animalMethodsX · 2019Article
- Semiconducting polymers are light nanotransducers in eyeless animals.Science advances · 2017Article
- Hydra as a model organism to decipher the toxic effects of copper oxide nanorod: Eco-toxicogenomics approach.Scientific reports · 2016Article
- Impact of Carbon Nano-Onions onNanomaterials (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is generally accepted that silica (SiO2) is not toxic. But the increasing use of silica nanoparticles (SiO2NPs) in many different industrial fields has prompted the careful investigation of their toxicity in biological systems. In this report, we describe the effects elicited by SiO2NPs on animal and cell physiology. Stable and monodisperse amorphous silica nanoparticles, 25 nM in diameter, were administered to living Hydra vulgaris (Cnidaria). The dose-related effects were defined by morphological and behavioral assays. The results revealed an all-or-nothing lethal toxicity with a rather high threshold (35 nM NPs) and a LT50 of 38 h. At sub lethal doses, the morphophysiological effects included: animal morphology alterations, paralysis of the gastric region, disorganization and depletion of tentacle specialized cells, increase of apoptotic and collapsed cells, and reduction of the epithelial cell proliferation rate. Transcriptome analysis (RNAseq) revealed 45 differentially expressed genes, mostly involved in stress response and cuticle renovation. Our results show that Hydra reacts to SiO2NPs, is able to rebalance the animal homeostasis up to a relatively high doses of SiO2NPs, and that the physiological modifications are transduced to gene expression modulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.