ReviewFrontiers in cellular and infection microbiology2014
Defining the metabolic requirements for the growth and colonization capacity of Campylobacter jejuni.
Review in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 137 citations in OpenAlex.
- Lactococcus cremoris decreases virulence‑associated properties, and modifies the protein profile of foodborne pathogen Campylobacter jejuni in biofilm.Gut pathogens · 2026Article
- Genomic insights into Campylobacter jejuni from Norwegian broilers: high genetic diversity and limited persistence on farms.BMC microbiology · 2026Article
- Limitations and safety aspects related to the use of bacteriophages in food production.FEMS microbiology reviews · 2026Article
- Transport of the abundant intestinal amino acid glutamine by the enteric pathogenMicrobiology (Reading, England) · 2026Article
- AProceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Investigating the Potential of L(+)-Lactic Acid as a Green Inhibitor and Eradicator of a Dual-SpeciesMicroorganisms · 2024Article
- Activation of the l-fucose utilization cluster inHeliyon · 2024Article
- Multi-Omics ofMicroorganisms · 2024Article
- Gut metabolite L-lactate supportsProceedings of the National Academy of Sciences of the United States of America · 2024Article
- QcrC is a potential target for antibody therapy and vaccination to controlFrontiers in microbiology · 2024Article
- Campylobacter jejuni and casein hydrolysate addition: Impact on poultry in vitro cecal microbiota and metabolome.PloS one · 2024Article
- Evolution and Role of Proteases inBiomolecules · 2023Review
- Metabolomic signatures of intestinal colonization resistance againstFrontiers in microbiology · 2023Article
- The Use of Interdisciplinary Approaches to Understand the Biology ofMicroorganisms · 2022Review
- Identification of genes associated with environmental persistence in Campylobacter jejuni and Campylobacter coli isolates from processing in a broiler abattoir.Veterinary research communications · 2022Article
- Luminal and mucosa-associated caecal microbiota of chickens after experimentalMicrobial genomics · 2022Article
- Substrate Utilisation and Energy Metabolism in Non-GrowingMicroorganisms · 2022Article
- The Retrospective on AtypicalMicroorganisms · 2022Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last decade Campylobacter jejuni has been recognized as the leading cause of bacterial gastroenteritis worldwide. This facultative intracellular pathogen is a member of the Epsilonproteobacteria and requires microaerobic atmosphere and nutrient rich media for efficient proliferation in vitro. Its catabolic capacity is highly restricted in contrast to Salmonella Typhimurium and other enteropathogenic bacteria because several common pathways for carbohydrate utilization are either missing or incomplete. Despite these metabolic limitations, C. jejuni efficiently colonizes various animal hosts as a commensal intestinal inhabitant. Moreover, C. jejuni is tremendously successful in competing with the human intestinal microbiota; an infectious dose of few hundreds bacteria is sufficient to overcome the colonization resistance of humans and can lead to campylobacteriosis. Besides the importance and clear clinical manifestation of this disease, the pathogenesis mechanisms of C. jejuni infections are still poorly understood. In recent years comparative genome sequence, transcriptome and metabolome analyses as well as mutagenesis studies combined with animal infection models have provided a new understanding of how the specific metabolic capacity of C. jejuni drives its persistence in the intestinal habitat of various hosts. Furthermore, new insights into the metabolic requirements that support the intracellular survival of C. jejuni were obtained. Because C. jejuni harbors distinct properties in establishing an infection in comparison to pathogenic Enterobacteriaceae, it represents an excellent organism for elucidating new aspects of the dynamic interaction and metabolic cross talk between a bacterial pathogen, the microbiota and the host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.