Evidence map›Paper›PMID 25324996›Full record

ReviewClinical endoscopy2014

Peroral endoscopic myotomy: establishing a new program.

Nikhil A Kumta, Shivani Mehta, Prashant Kedia, Kristen Weaver, Reem Z Sharaiha, Norio Fukami, Hitomi Minami, Fernando Casas, Monica Gaidhane, Arnon Lambroza and 1 more

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Clinical endoscopy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02162589 unknown statusnot on this map

Peroral Endoscopic Myotomy (POEM) For The Treatment Of Achalasia: A Retrospective And Prospective Multicenter Registry.

Typeobservational_patient_registrySponsorWeill Medical College of Cornell UniversityRan2014 to 2018Enrolled200ConditionsAchalasiaArmsPOEM
NCT02425033 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Endoscopic Submucosal Tunnel Dissection for Endoluminal Partial Myotomy of the Lower Esophageal Sphincter in Patients With Spastic Esophageal Disorders Such as Achalasia

TypeinterventionalSponsorUniversity Health Network, TorontoRan2015 to 2018Enrolled50ConditionsEsophageal AchalasiaArmsPOEM
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Observational
  7. Review
  8. Article
  9. Idiopathic (primary) achalasia: a review.Orphanet journal of rare diseases · 2015
    Review
  10. Peroral endoscopic myotomy: an evolving treatment for achalasia.Nature reviews. Gastroenterology & hepatology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Nikhil A KumtaDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Shivani MehtaDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Prashant KediaDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Kristen WeaverDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Reem Z SharaihaDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Norio FukamiDivision of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Hitomi MinamiDepartment of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan.
Fernando CasasGastroenterología y Endoscopia Digestiva, Hospital Central de la Policía Nacional, Bogota, Colombia.
Monica GaidhaneDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Arnon LambrozaDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Michel KahalehDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Cornell University · USNagasaki University Hospital · JPUniversity of Colorado Anschutz Medical Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Achalasia is an esophageal motility disorder characterized by incomplete relaxation of the lower esophageal sphincter (LES) and aperistalsis of the esophageal body. Treatment of achalasia is aimed at decreasing the resting pressure in the LES. Peroral endoscopic myotomy (POEM), derived from natural orifice transluminal endoscopic surgery (NOTES) and advances in endoscopic submucosal dissection (ESD), presents a novel, minimally invasive, and curative endoscopic treatment for achalasia. POEM involves an esophageal mucosal incision followed by creation of a submucosal tunnel crossing the esophagogastric junction and myotomy before closure of the mucosal incision. Although the procedure is technically demanding and requires a certain degree of skill and competency, treatment success is high (90%) with low complication rates. Since the first described POEM in humans in 2010, it has been used increasingly at centers worldwide. This article reviews available published clinical studies demonstrating POEM efficacy and safety in order to present a proposal on how to establish a dedicated POEM program and reach base proficiency for the procedure.

Indexed as

AchalasiaMyotomyNatural orifice endoscopic surgeryPeroral endoscopic myotomyTherapeutics

Identifiers

PMID25324996
PMCPMC4198553
OpenAlexW2008154148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.