Evidence map›Paper›PMID 25324965›Full record

ReviewF1000Research2014

Aging and energetics' 'Top 40' future research opportunities 2010-2013.

David B Allison, Lisa H Antoine, Scott W Ballinger, Marcas M Bamman, Peggy Biga, Victor M Darley-Usmar, Gordon Fisher, Julia M Gohlke, Ganesh V Halade, John L Hartman and 15 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in F1000Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 1 institution in 1 country.

David B AllisonOffice of Energetics, University of Alabama at Birmingham, Birmingham, USA ; School of Public Health, University of Alabama at Birmingham, Birmingham, USA ; Nutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA.
Lisa H AntoineOffice of Energetics, University of Alabama at Birmingham, Birmingham, USA ; School of Engineering, University of Alabama at Birmingham, Birmingham, USA ; Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, USA.
Scott W BallingerDepartment of Pathology, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA.
Marcas M BammanNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Cell, Developmental, & Integrative Biology, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA ; Birmingham VA Medical Center, Birmingham, USA.
Peggy BigaNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Biology, University of Alabama at Birmingham, Birmingham, USA.
Victor M Darley-UsmarNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Pathology, University of Alabama at Birmingham, Birmingham, USA ; Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, USA.
Gordon FisherNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Human Studies, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA.
Julia M GohlkeNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, USA.
Ganesh V HaladeNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Medicine - Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, USA.
John L HartmanNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Genetics, University of Alabama at Birmingham, Birmingham, USA.
Gary R HunterNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Human Studies, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA.
Joseph L MessinaNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Pathology, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA ; Birmingham VA Medical Center, Birmingham, USA.
Tim R NagyNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, USA ; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA.
Eric P PlaisanceNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Human Studies, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA.
Mickie L PowellNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Biology, University of Alabama at Birmingham, Birmingham, USA.
Kevin A RothNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Biology, University of Alabama at Birmingham, Birmingham, USA.
Michael W SandelNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, USA.
Tonia S SchwartzSchool of Public Health, University of Alabama at Birmingham, Birmingham, USA ; Nutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA.
Daniel L SmithNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, USA.
J David SweattUAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA.
Trygve O TollefsbolNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Biology, University of Alabama at Birmingham, Birmingham, USA.
Stephen A WattsNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Biology, University of Alabama at Birmingham, Birmingham, USA.
Yongbin YangNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, USA.
Jianhua ZhangCenter for Free Radical Biology, University of Alabama at Birmingham, Birmingham, USA.
Steven N AustadNutrition and Obesity Research Center, University of Alabama at Birmingham, Birmingham, USA ; Department of Biology, University of Alabama at Birmingham, Birmingham, USA ; Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, USA ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, USA.
University of Alabama at Birmingham · US

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill · 2000 to 2026
$31.9M
Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianhua Zhang · 2015 to 2026
$11.3M
UAB Statistical Genetics Post-Doctoral Training ProgramT32HL072757 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TIWARI, HEMANT K. · 2003 to 2016
$3.8M
NHLBI NIH HHS T32 HL072757NIDDK NIH HHS P30 DK056336
6 · The paper itself

Abstract

backgroundAs part of a coordinated effort to expand our research activity at the interface of Aging and Energetics a team of investigators at The University of Alabama at Birmingham systematically assayed and catalogued the top research priorities identified in leading publications in that domain, believing the result would be useful to the scientific community at large.

objectiveTo identify research priorities and opportunities in the domain of aging and energetics as advocated in the 40 most cited papers related to aging and energetics in the last 4 years.

designThe investigators conducted a search for papers on aging and energetics in Scopus, ranked the resulting papers by number of times they were cited, and selected the ten most-cited papers in each of the four years that include 2010 to 2013, inclusive.

resultsTen research categories were identified from the 40 papers.  These included: (1) Calorie restriction (CR) longevity response, (2) role of mTOR (mechanistic target of Rapamycin) and related factors in lifespan extension, (3) nutrient effects beyond energy (especially resveratrol, omega-3 fatty acids, and selected amino acids), 4) autophagy and increased longevity and health, (5) aging-associated predictors of chronic disease, (6) use and effects of mesenchymal stem cells (MSCs), (7) telomeres relative to aging and energetics, (8) accretion and effects of body fat, (9) the aging heart,  and (10) mitochondria, reactive oxygen species, and cellular energetics.

conclusionThe field is rich with exciting opportunities to build upon our existing knowledge about the relations among aspects of aging and aspects of energetics and to better understand the mechanisms which connect them.

Identifiers

PMID25324965
PMCPMC4197746
OpenAlexW2157915081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.