ReviewFrontiers in human neuroscience2014
The role of the hippocampus in flexible cognition and social behavior.
Review in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322212 (Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial), which is not on this map. Cited by 200 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial
Who cites it
200 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Relationships Between Immune-Inflammatory Features and Social Cognitive Impairments in Patients With Schizophrenia Spectrum Disorders: A Systematic Review.Brain and behavior · 2025Pooled it
- Social Communication in Ras Pathway Disorders: A Comprehensive Review From Genetics to Behavior in Neurofibromatosis Type 1 and Noonan Syndrome.Biological psychiatry · 2025Pooled it
- The role of gut microbiota on cognitive development in rodents: a meta-analysis.The journal of physiological sciences : JPS · 2023Pooled it
- Trial
- Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: mature data from a prospective trial in young patients with brain tumors.Neuro-oncology · 2020Trial
- Hippocampal Response to a 24-Month Physical Activity Intervention in Sedentary Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Trial
- Impairment of hippocampal gamma oscillations, mitochondria and neurovascular function in CADASIL.Brain : a journal of neurology · 2026Article
- Cognitive maps as a medium for thought.Trends in cognitive sciences · 2026Review
- Review
- Hippocampal Gene Expression in Zebra Finches Reveals Sex- and Subregion-Specific Topographies.eNeuro · 2026Article
- Stabilization of HSP70 by deubiquitinase OTUB1 attenuates sleep deprivation-induced cognitive impairment in mice.Journal of physiology and biochemistry · 2026Article
- General semantic, personal semantic and episodic details when thinking about the past and the future in moderate-to-severe traumatic brain injury.Scientific reports · 2026Article
- New neurons flatten social hierarchies.Scientific reports · 2026Article
- Review
- A mindfulness-based intervention to reduce altered brain reward function in cannabis use disorder: a double-blind, active and passive, randomised controlled fMRI trial.Psychopharmacology · 2026Article
- Amygdala and hippocampal contributions to broad autism phenotype: Project Ice Storm.Translational psychiatry · 2026Article
- Time-restricted feeding rescues sociability deficits and reduces neuroinflammation in aged mice.Neurobiology of aging · 2026Article
- Investigating brain-derived neurotrophic factor (BDNF) changes in three main rodent models of autism spectrum disorder (ASD): a systematic review.Neurotoxicity research · 2026Review
- Trans-Tissue Effects of Hippocampus- and Blood-Derived DNA Methylation Risk Scores on Bipolar Disorder Diagnosis.Bipolar disorders · 2026Article
- FMRP regulation of STAT3-MYC signaling is critical for adult hippocampal neurogenesis and cognitive flexibility.Cell death and differentiation · 2026Article
140 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Successful behavior requires actively acquiring and representing information about the environment and people, and manipulating and using those acquired representations flexibly to optimally act in and on the world. The frontal lobes have figured prominently in most accounts of flexible or goal-directed behavior, as evidenced by often-reported behavioral inflexibility in individuals with frontal lobe dysfunction. Here, we propose that the hippocampus also plays a critical role by forming and reconstructing relational memory representations that underlie flexible cognition and social behavior. There is mounting evidence that damage to the hippocampus can produce inflexible and maladaptive behavior when such behavior places high demands on the generation, recombination, and flexible use of information. This is seen in abilities as diverse as memory, navigation, exploration, imagination, creativity, decision-making, character judgments, establishing and maintaining social bonds, empathy, social discourse, and language use. Thus, the hippocampus, together with its extensive interconnections with other neural systems, supports the flexible use of information in general. Further, we suggest that this understanding has important clinical implications. Hippocampal abnormalities can produce profound deficits in real-world situations, which typically place high demands on the flexible use of information, but are not always obvious on diagnostic tools tuned to frontal lobe function. This review documents the role of the hippocampus in supporting flexible representations and aims to expand our understanding of the dynamic networks that operate as we move through and create meaning of our world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.