ArticleFrontiers in behavioral neuroscience2014
Social isolation during puberty affects female sexual behavior in mice.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Social isolation and loneliness associate with early menopause and mortality in women: a UK Biobank cohort study.BMC medicine · 2026Article
- Angolensin Isolated fromInternational journal of molecular sciences · 2025Article
- Shaping behaviors through social experience and their proposed sensitivity to stress.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Stress during pubertal development affects female sociosexual behavior in mice.Nature communications · 2024Article
- A role for nNOS in mediating stress and female sexual behavior in mice.Nature communications · 2024Article
- Long-term neuropeptide modulation of female sexual drive via the TRP channel inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Attraction of female house mice to male ultrasonic courtship vocalizations depends on their social experience and estrous stage.PloS one · 2023Article
- The effects of prenatal bisphenol A exposure on brain volume of children and young mice.Environmental research · 2022Article
- Insights into muscle stem cell dynamics during postnatal development.The FEBS journal · 2022Review
- The Impact of the SARS-CoV-2 Pandemic on Reproduction, Sexual Function and Behaviors: A Review of the Main Trends and Findings.International journal of sexual health : official journal of the World Association for Sexual Health · 2022Article
- Flexibility of neural circuits regulating mating behaviors in mice and flies.Frontiers in neural circuits · 2022Review
- The Role of the N-Methyl-D-Aspartate Receptors in Social Behavior in Rodents.International journal of molecular sciences · 2019Review
- Morphology of Mouse Anterior Cruciate Ligament-Complex Changes Following Exercise During Pubertal Growth.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice.Frontiers in behavioral neuroscience · 2019Article
- Neuroanatomical Substrates of Rodent Social Behavior: The Medial Prefrontal Cortex and Its Projection Patterns.Frontiers in neural circuits · 2017Review
- Review: Puberty as a time of remodeling the adult response to ovarian hormones.The Journal of steroid biochemistry and molecular biology · 2016Review
- Sex-specific effects of LiCl treatment on preservation of renal function and extended life-span in murine models of SLE: perspective on insights into the potential basis for survivorship in NZB/W female mice.Biology of sex differences · 2016Review
- Developmental Exposure to Ethinylestradiol Affects Reproductive Physiology, the GnRH Neuroendocrine Network and Behaviors in Female Mouse.Frontiers in neuroscience · 2015Article
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3 authors.
Funding
Abstract
Exposure to stress during puberty can lead to long-term behavioral alterations in adult rodents coincident with sex steroid hormone-dependent brain remodeling and reorganization. Social isolation is a stress for social animals like mice, but little is known about the effects of such stress during adolescence on later reproductive behaviors. The present study examined sexual behavior of ovariectomized, estradiol and progesterone primed female mice that were individually housed from 25 days of age until testing at approximately 95 days, or individually housed from day 25 until day 60 (during puberty), followed by housing in social groups. Mice in these isolated groups were compared to females that were group housed throughout the experiment. Receptive sexual behaviors of females and behaviors of stimulus males were recorded. Females housed in social groups displayed greater levels of receptive behaviors in comparison to both socially isolated groups. Namely, social females had higher lordosis quotients (LQs) and more often displayed stronger lordosis postures in comparison to isolated females. No differences between female groups were observed in stimulus male sexual behavior suggesting that female "attractiveness" was not affected by their social isolation. Females housed in social groups had fewer cells containing immunoreactive estrogen receptor (ER) α in the anteroventral periventricular nucleus (AVPV) and in the ventromedial nucleus of the hypothalamus (VMH) than both isolated groups. These results suggest that isolation during adolescence affects female sexual behavior and re-socialization for 1 month in adulthood is insufficient to rescue lordosis behavior from the effects of social isolation during the pubertal period.
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