ReviewFrontiers in cellular neuroscience2014
Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis.
Review in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Tissue tropism and mRNA expression profiles of selected innate immunity-related genes following experimental tick-borne encephalitis virus and louping ill virus infection of sheep.Journal of virology · 2026Article
- Spatial gene expression analysis reveals pathological niches in Japanese encephalitis virus neuroinvasion.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- "Silent messengers of chaos: unveiling the dual threat of immune infiltrates in Japanese encephalitis virus neuroinflammatory storm".Virology journal · 2025Review
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- Temporal tracking of microglial and monocyte single-cell transcriptomics in lethal flavivirus infection.Acta neuropathologica communications · 2023Article
- EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death.Viruses · 2022Article
- The increased intrathecal expression of the monocyte-attracting chemokines CCL7 and CXCL12 in tick-borne encephalitis.Journal of neurovirology · 2021Article
- Mayaro Virus Infects Human Brain Cells and Induces a Potent Antiviral Response in Human Astrocytes.Viruses · 2021Article
- Article
- Synthetic Host Defense Peptides Inhibit Venezuelan Equine Encephalitis Virus Replication and the Associated Inflammatory Response.Scientific reports · 2020Article
- Beyond HIV infection: Neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases.Virus research · 2020Review
- Study of Usutu virus neuropathogenicity in mice and human cellular models.PLoS neglected tropical diseases · 2020Article
- Recall Responses from Brain-Resident Memory CD8iScience · 2019Article
- PD1Virologica Sinica · 2019Article
- Chemokines and matrix metalloproteinases in cerebrospinal fluid of patients with central nervous system complications caused by varicella-zoster virus.Journal of neuroinflammation · 2019Article
- Article
- Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages.Cell host & microbe · 2018Article
- Infection with flaviviruses requires BCLXL for cell survival.PLoS pathogens · 2018Article
- CD14Nature microbiology · 2017Article
- CXCL11 production in cerebrospinal fluid distinguishes herpes simplex meningitis from herpes simplex encephalitis.Journal of neuroinflammation · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central nervous system (CNS) is a highly complex network comprising long-lived neurons and glial cells. Accordingly, numerous mechanisms have evolved to tightly regulate the initiation of inflammatory responses within the brain. Under neuroinflammatory conditions, as in the case of viral encephalitides, the infiltration of leukocytes is often required for efficient viral clearance and recovery. The orchestration of leukocyte migration into the inflamed CNS is largely coordinated by a large family of chemotactic cytokines and their receptors. In this review, we will summarize our current understanding of how chemokines promote protection or pathogenesis during arbovirus induced encephalitis, focusing on neurotropic flaviviruses and alphaviruses. Furthermore, we will highlight the latest developments in chemokine and chemokine receptor based drugs that could have potential as therapeutics and have been shown to play a pivotal role in shaping the outcome of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.