The Effect of Acetyl Salicylic Acid Induced Nitric Oxide Synthesis in the Normalization of Hypertension through the Stimulation of Renal Cortexin Synthesis and by the Inhibition of Dermcidin Isoform 2, A Hypertensive Protein Production.

Rajeshwary Ghosh, Sarbashri Bank, Uttam K Maji, Rabindra Bhattacharya, Santanu Guha, Nighat N Khan, A Kumar Sinha

Open access · greenAbstract read

In one paragraph

Article in International journal of biomedical science : IJBS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.2field-weighted citation impact, top 40% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

Low-Dose Aspirin Treatment Attenuates Male Rat Salt-Sensitive Hypertension via Platelet Cyclooxygenase 1 and Complement Cascade Pathway.Journal of the American Heart Association · 2020
Article
Effects of Aspirin on Endothelial Function and Hypertension.Current hypertension reports · 2016
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rajeshwary GhoshSinha Institute of Medical Science and Technology, Garia 700084, India;

Sarbashri BankSinha Institute of Medical Science and Technology, Garia 700084, India;

Uttam K MajiSinha Institute of Medical Science and Technology, Garia 700084, India;

Rabindra BhattacharyaGandhi Memorial Hospital, Kalyani, 741245, West Bengal, India;

Santanu GuhaDept. Of Cardiology, Calcutta Medical College and Hospital, Kolkata, India;

Nighat N KhanRR&D Center of Excellence, James J. Peters VA Medical Center, 130 W. Kingsbridge Road, Bronx, NY, USA;

A Kumar SinhaSinha Institute of Medical Science & Technology, 288, Kendua main road, Garia, 700 084, India.

Sinha Institute of Medical Science & Technology · INJames J. Peters VA Medical Center · USMedical College and Hospital, Kolkata · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, there is no specific medication for essential hypertension (EH), a major form of the condition, in man. As acetyl salicylic acid (aspirin) is reported to stimulate the synthesis of renal (r)-cortexin, an anti-essential hypertensive protein, and, as aspirin is reported to inhibit dermcidin isoform 2 (dermcidin), a causative protein for EH, the role of aspirin in the control of EH in man was studied. Oral administration of 150 mg aspirin/70 kg body weight in subjects with EH was found to reduce both the elevated systolic and diastolic blood pressures to normal levels within 3 h due to the normalization of dermcidin level in these subjects. The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994). In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)-cortexin synthesis due to NO synthesis. It could be suggested that the use of aspirin might control EH in man.

Indexed as

Antihypertensive medicationsAspirinDermcidin Isoform 2Nitric Oxide(r)-Cortexin

Identifiers

PMID25324696

PMCPMC4199471

OpenAlexW140038930

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.