Evidence map›Paper›PMID 25324574›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2015

Increased vascular calcification in patients receiving warfarin.

Ekamol Tantisattamo, Kum Hyun Han, W Charles O'Neill

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03446794 (Registry of Left Atrial Appendage Occlusion With WATCHMAN® Device in Patients With Non-valvular Atrial Fibrillation and End-stage Chronic Kidney Disease on Hemodialysis), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03446794 completednot on this mapstarted 2018, after this paper: background citation

Registry of Left Atrial Appendage Occlusion With WATCHMAN® Device in Patients With Non-valvular Atrial Fibrillation and End-stage Chronic Kidney Disease on Hemodialysis

Typeobservational_patient_registrySponsorFundación EPICRan2018 to 2022Enrolled300ConditionsAtrial Fibrillation, Heart Diseases, Renal Disease, BleedingArmsNon Intervention
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Roles of vitamin K‑dependent protein in biomineralization (Review).International journal of molecular medicine · 2024
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Hormonal regulation of biomineralization.Nature reviews. Endocrinology · 2021
    Review
  12. Review
  13. Review
  14. Role of Inflammation in Arterial Calcification.Korean circulation journal · 2021
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ekamol TantisattamoFrom the Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA (E.T., K.H.H., C.O.N.); and Department of Internal Medicine, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea (K.H.H).
Kum Hyun HanFrom the Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA (E.T., K.H.H., C.O.N.); and Department of Internal Medicine, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea (K.H.H).
W Charles O'NeillFrom the Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA (E.T., K.H.H., C.O.N.); and Department of Internal Medicine, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea (K.H.H). woneill@emory.edu.
Inje University Ilsan Paik Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMatrix gla protein is a vitamin K-dependent inhibitor of medial arterial calcification whose synthesis and activity are blocked by warfarin. Warfarin induces arterial calcification in experimental models, but whether this occurs in humans is unclear. This was addressed by examining breast arterial calcification, which is exclusively medial and easily identified on mammograms. APPROACH AND

resultsScreening mammograms from women with current, past, or future warfarin use were examined for the presence of arterial calcification and compared with mammograms obtained in untreated women matched for age and diabetes mellitus. Women with a serum creatinine >2.0 mg/dL or a history of end-stage renal disease were excluded. In 451 women with mammograms performed after ≥1 month of warfarin therapy, the prevalence of arterial calcification was 50% greater than in 451 untreated women (39.0% versus 25.9%; P<0.0001). However, in 159 mammograms performed before warfarin therapy, the prevalence of arterial calcification was not increased (26.4% versus 25.8%). The increased prevalence varied with duration of treatment, from 25.0% for <1 year to 74.4% for >5 years. In a multivariable logistic model, only age and duration of warfarin, but not the period of time after stopping warfarin, were significant determinants of arterial calcification in women with current or past warfarin use.

conclusionsThe prevalence of breast arterial calcification is increased in women with current or past warfarin use independent of other risk factors and conditions predating warfarin use. This effect appears to be cumulative and may be irreversible.

Indexed as

AdultAgedAged, 80 and overAnticoagulantsBreast DiseasesCase-Control StudiesChi-Square DistributionDrug Administration ScheduleFemaleGeorgiaHumansLogistic ModelsMammographyMiddle AgedMultivariate AnalysisPrevalenceAnticoagulantsWarfarinanticoagulationmatrix proteinsvascular calcification

Identifiers

PMID25324574
OpenAlexW2011543047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.