Evidence map›Paper›PMID 25324489›Full record

ArticleOccupational and environmental medicine2015

Biomechanical risk factors for carpal tunnel syndrome: a pooled study of 2474 workers.

Carisa Harris-Adamson, Ellen A Eisen, Jay Kapellusch, Arun Garg, Kurt T Hegmann, Matthew S Thiese, Ann Marie Dale, Bradley Evanoff, Susan Burt, Stephen Bao and 4 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Occupational and environmental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 185 citations in OpenAlex.

  1. The impact of handheld devices on the wrist and thumb: a systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Carisa Harris-AdamsonDepartment of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA Department of Physical Therapy, Samuel Merritt University, Oakland, California, USA.
Ellen A EisenDepartment of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA.
Jay KapelluschCenter for Ergonomics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Arun GargCenter for Ergonomics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Kurt T HegmannRocky Mountain Center for Occupational and Environmental Health (RMCOEH), University of Utah, Salt Lake City, Utah, USA.
Matthew S ThieseRocky Mountain Center for Occupational and Environmental Health (RMCOEH), University of Utah, Salt Lake City, Utah, USA.
Ann Marie DaleDivision of General Medical Science, Washington University School of Medicine, Saint Louis, Missouri, USA.
Bradley EvanoffDivision of General Medical Science, Washington University School of Medicine, Saint Louis, Missouri, USA.
Susan BurtPreviously with the National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, USA.
Stephen BaoSafety and Health Assessment and Research for Prevention (SHARP) Program, Washington State Department of Labor and Industries, Olympia, Washington, USA.
Barbara SilversteinSafety and Health Assessment and Research for Prevention (SHARP) Program, Washington State Department of Labor and Industries, Olympia, Washington, USA.
Linda MerlinoDepartment of Occupational and Environmental Health, University of Iowa, College of Public Health, Iowa City, Iowa, USA.
Fred GerrDepartment of Occupational and Environmental Health, University of Iowa, College of Public Health, Iowa City, Iowa, USA.
David RempelDivision of Occupational and Environmental Medicine, University of California at San Francisco, San Francisco, California, USA Department of Bioengineering, University of California Berkeley, Berkeley, California, USA.
United States Department of State · USUniversity of Iowa · USUniversity of Wisconsin–Milwaukee · USWashington University in St. Louis · USNational Institute for Occupational Safety and Health · USRocky Mountain University of Health Professions · USSamuel Merritt University · USUniversity of California, Berkeley · USUniversity of California, San Francisco · USUniversity of Utah · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
A Pooled Longitudinal Analysis of Workplace Carpal Tunnel SyndromeR01OH009712 · OH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REMPEL, DAVID M · 2010 to 2012
$1.5M
NCATS NIH HHS UL1 TR000448NIOSH CDC HHS R01 OH009712NIOSH CDC HHS R01OH009712
6 · The paper itself

Abstract

backgroundBetween 2001 and 2010, five research groups conducted coordinated prospective studies of carpal tunnel syndrome (CTS) incidence among US workers from various industries and collected detailed subject-level exposure information with follow-up of symptoms, electrophysiological measures and job changes.

objectiveThis analysis examined the associations between workplace biomechanical factors and incidence of dominant-hand CTS, adjusting for personal risk factors.

methods2474 participants, without CTS or possible polyneuropathy at enrolment, were followed up to 6.5 years (5102 person-years). Individual workplace exposure measures of the dominant hand were collected for each task and included force, repetition, duty cycle and posture. Task exposures were combined across the workweek using time-weighted averaging to estimate job-level exposures. CTS case-criteria were based on symptoms and results of electrophysiological testing. HRs were estimated using Cox proportional hazard models.

resultsAfter adjustment for covariates, analyst (HR=2.17; 95% CI 1.38 to 3.43) and worker (HR=2.08; 95% CI 1.31 to 3.39) estimated peak hand force, forceful repetition rate (HR=1.84; 95% CI 1.19 to 2.86) and per cent time spent (eg, duty cycle) in forceful hand exertions (HR=2.05; 95% CI 1.34 to 3.15) were associated with increased risk of incident CTS. Associations were not observed between total hand repetition rate, per cent duration of all hand exertions, or wrist posture and incident CTS.

conclusionsIn this prospective multicentre study of production and service workers, measures of exposure to forceful hand exertion were associated with incident CTS after controlling for important covariates. These findings may influence the design of workplace safety programmes for preventing work-related CTS.

Indexed as

AdultBiomechanical PhenomenaCarpal Tunnel SyndromeFemaleFollow-Up StudiesHand StrengthHumansIncidenceMaleMedian NerveMiddle AgedOccupational DiseasesPostureProspective StudiesRisk FactorsTime Factorsentrapment neuropathyphysical exposureprospectiveupper extremity

Identifiers

PMID25324489
PMCPMC4270859
OpenAlexW2135101789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.