Evidence map›Paper›PMID 25324440›Full record

Trial reportJournal of perinatal medicine2015

MR imaging of the fetal brain at 1.5T and 3.0T field strengths: comparing specific absorption rate (SAR) and image quality.

Uday Krishnamurthy, Jaladhar Neelavalli, Swati Mody, Lami Yeo, Pavan K Jella, Sheena Saleem, Steven J Korzeniewski, Maria D Cabrera, Shadi Ehterami, Ray O Bahado-Singh and 5 more

Abstract readClinical TrialComparative Study
In one paragraph

Trial report in Journal of perinatal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Fetal MRI: Radiofrequency Safety Assessment at 3 Tesla.Journal of magnetic resonance imaging : JMRI · 2025
    Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Safety of Magnetic Resonance Imaging in Pregnancy.Radiologie (Heidelberg, Germany) · 2023
    Review
  12. Fetal MRI: what's new? A short review.European radiology experimental · 2023
    Review
  13. Observational
  14. Article
  15. SVoRT: Iterative Transformer for Slice-to-Volume Registration in Fetal Brain MRI.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2022
    Article
  16. Review
  17. Article
  18. Fetal Neuroimaging Updates.Magnetic resonance imaging clinics of North America · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Uday Krishnamurthy
Jaladhar Neelavalli
Swati Mody
Lami Yeo
Pavan K Jella
Sheena Saleem
Steven J Korzeniewski
Maria D Cabrera
Shadi Ehterami
Ray O Bahado-Singh
Yashwanth Katkuri
Ewart M Haacke
Edgar Hernandez-Andrade
Sonia S Hassan
Roberto Romero

Funding

Prenatal Diagnosis Of Congenital AnomaliesZIAHD002401 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ROMERO, ROBERTO · 2009 to 2025
$81.1M
Development of flow and vascular quantification software for the assessment of MRR42HL112580 · NHLBI · MAGNETIC RESONANCE INNOVATIONS, INC. · PI HAACKE, EWART MARK · 2012 to 2014
$1.1M
Intramural NIH HHS ZIA HD002401NHLBI NIH HHS 1R42HL112580-01A1NHLBI NIH HHS R42 HL112580
6 · The paper itself

Abstract

objectivesOur two objectives were to evaluate the feasibility of fetal brain magnetic resonance imaging (MRI) using a fast spin echo sequence at 3.0T field strength with low radio frequency (rf) energy deposition (as measured by specific absorption rate: SAR) and to compare image quality, tissue contrast and conspicuity between 1.5T and 3.0T MRI.

methodsT2 weighted images of the fetal brain at 1.5T were compared to similar data obtained in the same fetus using a modified sequence at 3.0T. Quantitative whole-body SAR and normalized image signal to noise ratio (SNR), a nominal scoring scheme based evaluation of diagnostic image quality, and tissue contrast and conspicuity for specific anatomical structures in the brain were compared between 1.5T and 3.0T.

resultsTwelve pregnant women underwent both 1.5T and 3.0T MRI examinations. The image SNR was significantly higher (P=0.03) and whole-body SAR was significantly lower (P<0.0001) for images obtained at 3.0T compared to 1.5T. All cases at both field strengths were scored as having diagnostic image quality. Images from 3.0T MRI (compared to 1.5T) were equal (57%; 21/37) or superior (35%; 13/37) for tissue contrast and equal (61%; 20/33) or superior (33%, 11/33) for conspicuity.

conclusionsIt is possible to obtain fetal brain images with higher resolution and better SNR at 3.0T with simultaneous reduction in SAR compared to 1.5T. Images of the fetal brain obtained at 3.0T demonstrated superior tissue contrast and conspicuity compared to 1.5T.

Indexed as

AdultBrainFemaleFetusHumansMagnetic Resonance ImagingNeuroimagingPregnancyPrenatal DiagnosisProspective StudiesYoung Adult

Identifiers

PMID25324440
PMCPMC5987203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.