ArticleTropical medicine & international health : TM & IH2015
Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia.
Article in Tropical medicine & international health : TM & IH, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A new point-of-care test for the rapid antimicrobial susceptibility assessment of uropathogens.PloS one · 2023Trial
- Urine bioassay optimisation to assess the association between antimicrobial exposure, pneumococcal carriage and antimicrobial resistance among hospitalised children in Malawi.BMC infectious diseases · 2025Article
- Use of antimicrobials and other medical products in an ethnic minority context of South-Central Vietnam: A qualitative study of vulnerability.PLOS global public health · 2024Article
- The impact of C-reactive protein testing on treatment-seeking behavior and patients' attitudes toward their care in Myanmar and Thailand.Healthcare in low-resource settings · 2023Article
- Public knowledge, attitudes and practices surrounding antibiotic use and resistance in Cambodia.JAC-antimicrobial resistance · 2021Article
- Frequent unregulated use of antibiotics in rural Cambodian infants.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2020Article
- Carriage of carbapenemase- and extended-spectrum cephalosporinase-producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of blaZoonoses and public health · 2019Article
- Epidemiology of paediatric gastrointestinal colonisation by extended spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates in north-west Cambodia.BMC microbiology · 2019Article
- Frequent Community Use of Antibiotics among a Low-Economic Status Population in Manila, the Philippines: A Prospective Assessment Using a Urine Antibiotic Bioassay.The American journal of tropical medicine and hygiene · 2018Article
- Pervasive antibiotic misuse in the Cambodian community: antibiotic-seeking behaviour with unrestricted access.Antimicrobial resistance and infection control · 2017Article
- High Prevalence of Antimicrobial-resistant Gram-negative Colonization in Hospitalized Cambodian Infants.The Pediatric infectious disease journal · 2016Article
- Antimicrobial susceptibility of uropathogens isolated from Cambodian children.Paediatrics and international child health · 2016Article
- Article
- Characterisation of Invasive Streptococcus pneumoniae Isolated from Cambodian Children between 2007 - 2012.PloS one · 2016Article
- Pneumococcal Infection among Children before Introduction of 13-Valent Pneumococcal Conjugate Vaccine, Cambodia.Emerging infectious diseases · 2015Article
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8 authors.
Funding
Abstract
objectiveAntibiotic resistance is a prominent public and global health concern. We investigated antibiotic use in children by determining the proportion of unselected children with antibacterial activity in their urine attending a paediatric outpatient department in Siem Reap, Cambodia.
methodsCaregiver reports of medication history and presence of possible infection symptoms were collected in addition to urine samples. Urine antibiotic activity was estimated by exposing bacteria to urine specimens, including assessment against multiresistant bacteria previously isolated from patients in the hospital (a methicillin-resistant Staphylococcus aureus (MRSA), a multiresistant Salmonella typhi and an extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolate).
resultsMedication information and urine were collected from 775 children. Caregivers reported medication use in 69.0% of children in the preceding 48 h. 31.7% samples showed antibacterial activity; 16.3% showed activity against a local multiresistant organism. No specimens demonstrated activity against an ESBL-producing E. coli.
conclusionsAntibiotics are widely used in the community setting in Cambodia. Parents are often ill-informed about drugs given to treat their children. Increasing the regulation and training of private pharmacies in Cambodia may be necessary. Regional surveillance of antibiotic use and resistance is also essential in devising preventive strategies against further development of antibiotic resistance, which would have both local and global consequences.
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