ArticleMolecular medicine reports2014
D‑galactose‑induced mitochondrial DNA oxidative damage in the auditory cortex of rats.
Article in Molecular medicine reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Formulation and evaluation of probucol-LCA nanoparticles for supressing oxidative stress-related retinal degeneration.Drug delivery and translational research · 2026Article
- D-galactose-induced mitochondrial oxidative damage and apoptosis in the cochlear stria vascularis of mice.BMC molecular and cell biology · 2023Article
- D-Galactose and Hypoxia Induce the Early Onset of Age-Related Hearing Loss Deterioration in a Mouse Model.Tissue engineering and regenerative medicine · 2023Article
- AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo.Molecular medicine (Cambridge, Mass.) · 2022Article
- D-Galactose-Induced Accelerated Aging Model on Auditory Cortical Neurons by Regulating Oxidative Stress and Apoptosis in Vitro.The journal of nutrition, health & aging · 2022Article
- Ginseng gintonin, aging societies, and geriatric brain diseases.Integrative medicine research · 2021Review
- Frailty Syndrome and Oxidative Stress as Possible Links Between Age-Related Hearing Loss and Alzheimer's Disease.Frontiers in neuroscience · 2021Review
- Effect of SOD2 methylation on mitochondrial DNA4834-bp deletion mutation in marginal cells under oxidative stress.Bosnian journal of basic medical sciences · 2020Article
- Galactose-Induced Skin Aging: The Role of Oxidative Stress.Oxidative medicine and cellular longevity · 2020Review
- Protective Effects of Silymarin Against Age-Related Hearing Loss in an Aging Rat Model.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2019Article
- Grape Seed Proanthocyanidin Extract Prevents Ovarian Aging by Inhibiting Oxidative Stress in the Hens.Oxidative medicine and cellular longevity · 2018Article
- Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in d-galactose-induced aging rats.Clinical interventions in aging · 2017Article
- Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats.Molecular medicine reports · 2016Article
- Sevoflurane Post-conditioning Enhanced Hippocampal Neuron Resistance to Global Cerebral Ischemia Induced by Cardiac Arrest in Rats through PI3K/Akt Survival Pathway.Frontiers in cellular neuroscience · 2016Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic administration of D‑galactose (D‑gal) is a useful method for establishing a model of natural aging in the auditory system. Previous studies have demonstrated that NADPH oxidases (NOXs) may be an important source of reactive oxygen species (ROS) in the peripheral auditory system (PAS) and cause an increase in mitochondrial DNA (mtDNA) common deletion (CD) levels in the PAS and central auditory system (CAS) of rats with D‑gal‑induced aging. However, the source of the ROS in the CAS and the mechanisms of age‑related hearing loss (ARHL) have yet to be elucidated. In the present study, male Sprague Dawley rats were administered a daily injection of D‑gal (150, 300 and 500 mg/kg, respectively) for eight weeks. All three doses of D‑gal caused a significant increase in the expression of NOX2, 8‑hydroxy‑2‑deoxyguanosine, a biomarker of DNA oxidative damage, and uncoupling protein 2, together with a decrease in the mitochondrial total antioxidant capabilities in the auditory cortex, as compared with the control rats (injected daily with the same volume of 0.9% saline for eight weeks). The levels of the mtDNA CD were also increased in the auditory cortex of the D‑gal‑induced aging rats. These findings suggest that both NOX‑ and mitochondria‑associated ROS generation may contribute to mtDNA oxidative damage in the auditory cortex of the CAS of D‑gal‑induced aging rats. This study may provide novel insight into the development of ARHL.
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