ArticleClinical oral investigations2015
A biofilm cariogenic challenge model for dentin demineralization and dentin bonding analysis.
Article in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The role of etching protocols on bond strength of universal adhesives applied to caries affected dentin: a systematic review and meta-analysis.Clinical oral investigations · 2024Pooled it
- Influence of S-PRG-based restorative and adhesive systems on biofilm formation and enamel demineralization in a simulated oral environment.Clinical oral investigations · 2026Article
- Comparison of mineral precipitation, elemental release, pH change and cytotoxicity of calcium-silicate cements and an experimental resin-modified glass ionomer cement containing bioactive glass.Biomaterial investigations in dentistry · 2026Article
- Biochemical and Mechanical Analysis of Occlusal and Proximal Carious Lesions.Diagnostics (Basel, Switzerland) · 2022Article
- Effect of ionizing radiation and cariogenic biofilm challenge on root-dentin caries.Clinical oral investigations · 2021Article
- Chemo-mechanical characterization of carious dentine using Raman microscopy and Knoop microhardness.Royal Society open science · 2020Article
- Comparison between static and semi-dynamic models for microcosm biofilm formation on dentin.Journal of applied oral science : revista FOB · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study was designed to adapt a previously developed in vitro microcosm biofilm model to create carries-affected dentin (CAD) and establish conditions for using the model in bonding studies. MATERIALS AND
methodsBiofilms were originated from human saliva and grown on dentin discs for 0 (sound dentin), 3, 5, 7, 14, or 21 days under intermittent cariogenic condition (n = 10). At each time point, composite cylinders were bonded to the dentin using self-etch adhesive (Clearfil SE Bond). The response variables were integrated mineral loss (ΔS), lesion depth (LD), shear bond strength (SBS), and failure mode. Data were statistically analyzed (α = 0.05). Bonded interfaces were analyzed by scanning electron microscopy (SEM), and dentin surfaces characterized by infrared spectroscopy (Fourier transform infrared spectroscopy, FTIR).
resultsLower ΔS was found for sound dentin than for CAD in all experimental groups, except for the group under cariogenic challenge for 3 days. The SBS to CAD was significantly lower than control for all cariogenic challenge times. Adhesive failures were predominant in all groups. ΔS and LD had a significant negative correlation with SBS. A significant exponential decay in SBS was associated with increased ΔS values. CAD had lower mineral and amide I content and an irregular hybridization interface compared to sound dentin.
conclusionsThe microcosm biofilm model was able to artificially induce CAD, which imposed challenge to the bonding of the polymeric adhesive material. CLINICAL RELEVANCE: Presence of CAD might interfere with the bonding of polymeric materials. The microcosm biofilm model proposed could be useful for preclinical dentin bonding studies.
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