ArticleGenome biology and evolution2014
Faster-X effects in two Drosophila lineages.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- A population genomic resource for Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2026Article
- Interbreeding between Neanderthals and modern humans was strongly sex biased.Science (New York, N.Y.) · 2026Article
- Population genomics ofbioRxiv : the preprint server for biology · 2026Article
- Review
- Faster adaptation but slower divergence of X chromosomes under paternal genome elimination.Nature communications · 2025Article
- Reduced Efficacy of Selection on a Young Z Chromosome Region of Schistosoma japonicum.Genome biology and evolution · 2025Article
- Reconciling theories of dominance with the relative rates of adaptive substitution on sex chromosomes and autosomes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Enrichment of Hard Sweeps on the X Chromosome in Drosophila melanogaster.Molecular biology and evolution · 2023Article
- Influence of the large-Z effect during contact between butterfly sister species.Ecology and evolution · 2021Article
- Absence of a Faster-X Effect in Beetles (G3 (Bethesda, Md.) · 2020Article
- Evolutionary Dynamics of Sex Chromosomes of Paleognathous Birds.Genome biology and evolution · 2019Article
- Sexually dimorphic gene expression and transcriptome evolution provide mixed evidence for a fast-Z effect in Heliconius.Journal of evolutionary biology · 2019Article
- Support for the Dominance Theory inGenetics · 2018Article
- Increase in viability due to the accumulation of X chromosome mutations in Drosophila melanogaster males.Genetica · 2018Article
- Disentangling the Causes for Faster-X Evolution in Aphids.Genome biology and evolution · 2018Article
- Extensive exchange of transposable elements in theMobile DNA · 2018Article
- Hemizygosity Enhances Purifying Selection: Lack of Fast-Z Evolution in Two Satyrine Butterflies.Genome biology and evolution · 2016Article
- Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation in Drosophila melanogaster.Molecular ecology · 2016Article
- Molecular Mechanisms and Evolutionary Processes Contributing to Accelerated Divergence of Gene Expression on the Drosophila X Chromosome.Molecular biology and evolution · 2015Article
- Sex Bias and Maternal Contribution to Gene Expression Divergence in Drosophila Blastoderm Embryos.PLoS genetics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Under certain circumstances, X-linked loci are expected to experience more adaptive substitutions than similar autosomal loci. To look for evidence of faster-X evolution, we analyzed the evolutionary rates of coding sequences in two sets of Drosophila species, the melanogaster and pseudoobscura clades, using whole-genome sequences. One of these, the pseudoobscura clade, contains a centric fusion between the ancestral X chromosome and the autosomal arm homologous to 3L in D. melanogaster. This offers an opportunity to study the same loci in both an X-linked and an autosomal context, and to compare these loci with those that are only X-linked or only autosomal. We therefore investigated these clades for evidence of faster-X evolution with respect to nonsynonymous substitutions, finding mixed results. Overall, there was consistent evidence for a faster-X effect in the melanogaster clade, but not in the pseudoobscura clade, except for the comparison between D. pseudoobscura and its close relative, Drosophila persimilis. An analysis of polymorphism data on a set of genes from D. pseudoobscura that evolve rapidly with respect to their protein sequences revealed no evidence for a faster-X effect with respect to adaptive protein sequence evolution; their rapid evolution is instead largely attributable to lower selective constraints. Faster-X evolution in the melanogaster clade was not related to male-biased gene expression; surprisingly, however, female-biased genes showed evidence for faster-X effects, perhaps due to their sexually antagonistic effects in males.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.