ArticleEuropean journal of clinical pharmacology2014
Clozapine serum concentrations in dopamimetic psychosis in Parkinson's disease and related disorders.
Article in European journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Glycine and clozapine: potential relevance for the treatment of Parkinson's disease.Neurodegenerative disease management · 2024Article
- Trends and Contributing Factors for Prescribing Antipsychotics in Newly Diagnosed Parkinson's Disease Patients: A Population-Based Study.Risk management and healthcare policy · 2021Article
- Clozapine in the treatment of refractory schizophrenia: a practical guide for healthcare professionals.British medical bulletin · 2020Article
- Atypical antipsychotics for Parkinson's disease psychosis: a systematic review and meta-analysis.Neuropsychiatric disease and treatment · 2019Article
- Update on the treatment of Parkinson's disease psychosis: role of pimavanserin.Neuropsychiatric disease and treatment · 2017Review
- Parkinson's disease psychosis: therapy tips and the importance of communication between neurologists and psychiatrists.Neurodegenerative disease management · 2016Review
- Psychosis in Parkinson's disease: identification, prevention and treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
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8 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposePsychotic symptoms in Parkinson's disease (PD) caused by dopamimetic treatment are a relevant clinical problem. As clozapine does not cause extrapyramidal side effects, it is suitable for treatment of dopamimetic psychosis. The main aim of the present study was (1) to establish an indication-specific recommendation for therapeutic reference range of clozapine among patients with dopamimetic psychosis in PD and related disorders. Secondary goals were (2) to test whether clozapine therapy is safe and calculable despite pharmacokinetic changes expected in the study population and (3) to assess influencing variables on clozapine serum levels.
methodsWe carried out a retrospective chart review of patients suffering from dopamimetic psychosis as well as Lewy body dementia treated with clozapine. We extracted demographic and clinical data as well as results from therapeutic drug monitoring that was carried out via high-performance liquid chromatography in order to analyse clozapine and norclozapine serum concentrations.
resultsn = 35 patients could be identified and were included in the study. Mean age was 72.4 years. Clozapine treatment for patients with dopamimetic psychosis in PD and related disorders seems to be safe and calculable. Mean clozapine serum concentration was 77.9 ng/ml (SD 63.4 ng/ml). Clozapine dose is significantly correlated with serum clozapine concentration (r = 0.35; R (2) = 0.122). Women showed lower clozapine serum concentrations although they received higher weight-corrected clozapine doses.
conclusionsWe suggest an orienting indication-specific therapeutic reference range of 15-141 ng/ml among PD patients with dopamimetic psychosis. Therapeutic drug monitoring is recommended and might help to minimize the risk of adverse events by screening for unexpectedly high serum concentrations of clozapine.
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