Evidence map›Paper›PMID 25323747›Full record

ArticleScientific reports2014

Zebrafish as a model to study live mucus physiology.

Irena Jevtov, Tore Samuelsson, Grace Yao, Adam Amsterdam, Katharina Ribbeck

Abstract read
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. TheMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  3. Article
  4. Article
  5. The role of animal hosts in shaping gut microbiome variation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Silver Nanoparticles in Zebrafish (International journal of molecular sciences · 2020
    Article
  18. Review
  19. Polyphenols in the Fermentation Liquid ofFrontiers in immunology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Irena JevtovDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.
Tore SamuelssonDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
Grace YaoDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.
Adam AmsterdamDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVINE, STUART S · 1985 to 2020
$25.6M
Using Zebrafish to Identify and Analyze Cancer GenesR01CA106416 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEES, JACQUELINE A. · 2006 to 2010
$1.9M
NCI NIH HHS CA106416NCI NIH HHS R01 CA106416NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P30-ES002109
6 · The paper itself

Abstract

Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology.

Indexed as

AnimalsGastrointestinal TractModels, BiologicalMucinsMucusRespiratory SystemUrogenital SystemZebrafishMucins

Identifiers

PMID25323747
PMCPMC4200417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.