Trial reportEuropean radiology2015
Osteoporosis markers on low-dose lung cancer screening chest computed tomography scans predict all-cause mortality.
Trial report in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Opportunistic CT-based osteoporosis screening of the hip: a systematic review of diagnostic accuracy.Archives of orthopaedic and trauma surgery · 2025Pooled it
- Meta-research: How many diagnostic or prognostic models published in radiological journals are evaluated externally?European radiology · 2024Pooled it
- Automated Muscle Measurement on Chest CT Predicts All-Cause Mortality in Older Adults From the National Lung Screening Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Osteoporosis screening using computed tomography for men with prostate cancer: results of a prospective study.Archives of osteoporosis · 2020Trial
- Repeatability of AI-quantified incidental findings on lung cancer screening CT scans in the NELSON trial.European radiology · 2026Article
- Radiomics-Based Machine Learning for Sarcopenia Detection in Abdominal and Low-Dose CT.Diagnostics (Basel, Switzerland) · 2026Article
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- Article
- Prevalent findings on low-dose CT scan lung cancer screening: a French prospective pilot study.European journal of public health · 2025Article
- Incidental Findings in Lung Cancer Screening.Cancers · 2024Review
- How will lung cancer screening and lung nodule management change the diagnostic and surgical lung cancer landscape?European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Low-Dose Computed Tomography Scan Features Are Associated With Annual Risk of Hospitalization.Annals of thoracic surgery short reports · 2023Article
- Vertebral CT attenuation outperforms standard clinical fracture risk prediction tools in detecting osteoporotic disease in lung cancer screening participants.The British journal of radiology · 2023Article
- Ten reasons to screen women at risk of lung cancer.Insights into imaging · 2023Article
- ERS/ESTS/ESTRO/ESR/ESTI/EFOMP statement on management of incidental findings from low dose CT screening for lung cancer.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023Article
- Incidental findings on lung cancer screening: pictorial essay and systematic checklist.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022Article
- Osteoporosis in Patients With Respiratory Diseases.Frontiers in physiology · 2022Review
- Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults.Insights into imaging · 2021Article
- Associations of ADL Disability With Trunk Muscle Mass and Muscle Quality Indicators Measured by Opportunistic Chest Computed Tomography Imaging Among Older Inpatients.Frontiers in medicine · 2021Article
- Factors That Improve Chest Computed Tomography-Defined Sarcopenia Prognosis in Advanced Non-Small Cell Lung Cancer.Frontiers in oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesFurther survival benefits may be gained from low-dose chest computed tomography (CT) by assessing vertebral fractures and bone density. We sought to assess the association between CT-measured vertebral fractures and bone density with all-cause mortality in lung cancer screening participants.
methodsFollowing a case-cohort design, lung cancer screening trial participants (N = 3,673) who died (N = 196) during a median follow-up of 6 years (inter-quartile range: 5.7-6.3) were identified and added to a random sample of N = 383 from the trial. We assessed vertebral fractures using Genant's semiquantative method on sagittal reconstructions and measured bone density (Hounsfield Units (HU)) in vertebrae. Cox proportional hazards modelling was used to determine if vertebral fractures or bone density were independently predictive of mortality.
resultsThe prevalence of vertebral fractures was 35% (95% confidence interval 30-40%) among survivors and 51% (44-58%) amongst cases. After adjusting for age, gender, smoking status, pack years smoked, coronary and aortic calcium volume and pulmonary emphysema, the adjusted hazard ratio (HR) for vertebral fracture was 2.04 (1.43-2.92). For each 10 HU decline in trabecular bone density, the adjusted HR was 1.08 (1.02-1.15).
conclusionsVertebral fractures and bone density are independently associated with all-cause mortality. KEY POINTS: • Lung cancer screening chest computed tomography contains additional, potentially useful information. • Vertebral fractures and bone density are independently predictive of mortality. • This finding has implications for screening and management decisions.
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