ArticleNature communications2014
An authentic imaging probe to track cell fate from beginning to end.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Multiplexed optoacoustic tracking and magnetic actuation of labeled blood cells in living mice.Science advances · 2026Article
- Oxidative Degradation of Sequence-Defined Peptoid Oligomers.Molecular systems design & engineering · 2023Article
- Novel Pyrazine-Bridged D-A-D Type Charge Neutral Probe for Membrane Permeable Long-Term Live Cell Imaging.Frontiers in chemistry · 2021Article
- Whole-Body Fluorescence Imaging in the Near-Infrared Window.Advances in experimental medicine and biology · 2021Article
- Poly-d-lysine coated nanoparticles to identify pro-inflammatory macrophages.Nanoscale advances · 2020Article
- Assessing the range of enzymatic and oxidative tunability for biosensor design.Journal of materials chemistry. B · 2020Review
- Advanced Near-Infrared Light for Monitoring and Modulating the Spatiotemporal Dynamics of Cell Functions in Living Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Article
- Nanoparticle Delivery of miR-708 Mimetic Impairs Breast Cancer Metastasis.Molecular cancer therapeutics · 2019Article
- Deconstructing the pluripotency gene regulatory network.Nature cell biology · 2018Review
- Versatile Nanodelivery Platform to Maximize siRNA Combination Therapy.Macromolecular bioscience · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Accurate tracing of cell viability is critical for optimizing delivery methods and evaluating the efficacy and safety of cell therapeutics. A nanoparticle-based cell tracker is developed to image cell fate from live to dead. The particle is fabricated from two types of optically quenched polyelectrolytes, a life indicator and a death indicator, through electrostatic interactions. On incubation with cells, the fabricated bifunctional nanoprobes are taken up efficiently and the first colour is produced by normal intracellular proteolysis, reflecting the healthy status of the cells. Depending on the number of coated layers, the signal can persist for several replication cycles. However, as the cells begin dying, the second colour appears quickly to reflect the new cell status. Using this chameleon-like cell tracker, live cells can be distinguished from apoptotic and necrotic cells instantly and definitively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.