ArticleThe European respiratory journal2015
Asthma, airflow limitation and mortality risk in the general population.
Article in The European respiratory journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Association Between Asthma and All-Cause Mortality and Cardiovascular Disease Morbidity and Mortality: A Meta-Analysis of Cohort Studies.Frontiers in cardiovascular medicine · 2022Pooled it
- Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma.The New England journal of medicine · 2016Trial
- Genome-Wide Cross-Trait Analysis in European Populations Reveals Shared Genetic Architecture of Chronic Obstructive Pulmonary Disease and the Allergy Spectrum.International archives of allergy and immunology · 2025Article
- Persistent airway obstruction in severe eosinophilic asthma: targeting interleukin-5 and eosinophils.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Clinical remission of mild-to-moderate asthma: Rates, contributing factors, and stability.The journal of allergy and clinical immunology. Global · 2025Article
- Impact of Low Hand Grip Strength on Quality of Life, Utilization of Healthcare, and Mental Health in Individuals with Airflow Limitation.International journal of chronic obstructive pulmonary disease · 2025Article
- Distinct phenotype and risk factor analysis of persistent airflow limitation among asthmatic children: a case-control study.BMC pediatrics · 2024Article
- Clinical characteristics of obese, fixed airway obstruction, exacerbation-prone phenotype and comorbidities among severe asthma patients: a single-center study.BMC pulmonary medicine · 2024Article
- Level of Education Modifies Asthma Mortality in Norway and Sweden. The Nordic EpiLung Study.Journal of asthma and allergy · 2024Article
- Clinical features of asthma with connective tissue diseases.The clinical respiratory journal · 2023Article
- Rapid FEVJournal of Korean medical science · 2023Article
- Association of rheumatoid arthritis with bronchial asthma and asthma-related comorbidities: A population-based national surveillance study.Frontiers in medicine · 2023Article
- Respiratory-related death in individuals with incident asthma and COPD: a competing risk analysis.BMC pulmonary medicine · 2022Article
- Poor Asthma Control in Schoolchildren May Lead to Lower Lung Function Trajectory from Childhood to Early Adulthood: A Japanese Cohort Study.Journal of asthma and allergy · 2022Article
- Emphysema-Predominant COPD Had a Greater 5-Year Mortality and a Worse Annual Decline in Lung Function Than Airway Obstruction-Predominant COPD or Asthma at Initial Same Degree of Airflow Obstruction.Medicina (Kaunas, Lithuania) · 2021Observational
- Long-term predictors of severe exacerbations and mortality in a cohort of well-characterised adults with asthma.Respiratory research · 2021Observational
- Lung Function of Children Following an Intensive Care Unit Admission for Asthma.Pediatric allergy, immunology, and pulmonology · 2021Article
- Article
- Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets.BMC pulmonary medicine · 2020Article
- Possible risk factors for poor asthma control assessed in a cross-sectional population-based study from Telemark, Norway.PloS one · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Asthma and chronic obstructive pulmonary disease co-exist in a significant proportion of patients. Whether asthma increases mortality risk among subjects with airflow limitation remains controversial. We used data from 2121 adult participants in the population-based Tucson Epidemiological Study of Airway Obstructive Disease cohort. At enrolment (1972-1973), participants completed questionnaires and lung function tests. Participants were categorised into four groups based on the combination of airflow limitation (AL; forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <70%) and physician-confirmed asthma at baseline. Vital status as of January 2011 was assessed through the National Death Index. Cox proportional hazards models were used to test differences in mortality risk across the four airflow limitation/asthma groups. In multivariate Cox models, the AL+/asthma+ group had a 114% increased mortality risk during follow-up compared with the AL-/asthma- group (adjusted HR 2.14; 95% CI 1.64-2.79). The corresponding hazard ratios were 1.09 (95% CI 0.89-1.34) and 1.34 (95% CI 1.14-1.57) for the AL-/asthma+ and AL+/asthma- groups, respectively. Among subjects with airflow limitation, asthma was associated with increased mortality risk (HR 1.58, 95% CI 1.17-2.12). However, this increased risk was substantially reduced and no longer significant after further adjustment for baseline FEV1 levels. Similar results were obtained when airflow limitation was defined as FEV1/FVC less than the lower limit of normal. In a population-based cohort, subjects with concomitant airflow limitation and asthma had an increased risk of dying, which was mainly related to their baseline lung function deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.