ReviewEpileptic disorders : international epilepsy journal with videotape2014
What is more harmful, seizures or epileptic EEG abnormalities? Is there any clinical data?
Review in Epileptic disorders : international epilepsy journal with videotape, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04141332 (Specific Language Impairment), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Specific Language Impairment (SLI) in Children May Caused by Epileptic Brain Activity
Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Behavioral Timing of Interictal Spikes, But Not Rate, Correlates with Impaired Working Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Timing is everything: The effect of early-life seizures on developing neuronal circuits subserving spatial memory.Epilepsia open · 2025Review
- Interictal spikes during spatial working memory carry helpful or distracting representations of space and have opposing impacts on performance.bioRxiv : the preprint server for biology · 2024Article
- Review
- How cerebral cortex protects itself from interictal spikes: The alpha/beta inhibition mechanism.Human brain mapping · 2021Article
- Factors correlated with intracranial interictal epileptiform discharges in refractory epilepsy.Epilepsia · 2021Article
- Modulation of locomotor behaviors by location-specific epileptic spiking and seizures.Epilepsy & behavior : E&B · 2021Article
- Superior Verbal Memory Outcome After Stereotactic Laser Amygdalohippocampotomy.Frontiers in neurology · 2021Article
- Developmental Language Disorder: Wake and Sleep Epileptiform Discharges and Co-morbid Neurodevelopmental Disorders.Brain sciences · 2020Article
- Prediction of Cognitive Decline in Temporal Lobe Epilepsy and Mild Cognitive Impairment by EEG, MRI, and Neuropsychology.Computational intelligence and neuroscience · 2020Article
- The Oscillatory Basis of Working Memory Function and Dysfunction in Epilepsy.Frontiers in human neuroscience · 2020Review
- Functional brain connectivity in electrical status epilepticus in sleep.Epileptic disorders : international epilepsy journal with videotape · 2019Article
- The Paroxysmal Depolarization Shift: Reconsidering Its Role in Epilepsy, Epileptogenesis and Beyond.International journal of molecular sciences · 2019Review
- The Impact of Interictal Discharges on Performance.Current neurology and neuroscience reports · 2018Review
- Transient Cognitive Impairment in Epilepsy.Frontiers in molecular neuroscience · 2018Article
- Staged anticonvulsant screening for chronic epilepsy.Annals of clinical and translational neurology · 2016Article
- Spatial cognition following early-life seizures in rats: Performance deficits are dependent on task demands.Epilepsy & behavior : E&B · 2016Article
- Effect of Seizures on the Developing Brain and Cognition.Seminars in pediatric neurology · 2016Review
- Interictal epileptiform discharge effects on neuropsychological assessment and epilepsy surgical planning.Epilepsy & behavior : E&B · 2016Review
- Single-Gene Determinants of Epilepsy Comorbidity.Cold Spring Harbor perspectives in medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Cognitive impairment is a common and often devastating co-morbidity of childhood epilepsy. While the aetiology of the epilepsy is a critical determinant of cognitive outcome, there is considerable evidence from both rodent and human studies that indicate that seizures and interictal epileptiform abnormalities can contribute to cognitive impairment. A critical feature of childhood epilepsy is that the seizures and epileptiform activity occur in a brain with developing, plastic neuronal circuits. The consequences of seizures and interictal epileptiform activity in the developing brain differ from similar paroxysmal events occurring in the relatively fixed circuitry of the mature brain. In animals, it is possible to study interictal spikes independently from seizures, and it has been demonstrated that interictal spikes are as detrimental as seizures during brain development. In the clinic, distinguishing the differences between interictal spikes and seizures is more difficult, since both typically occur together. However, both seizures and interictal spikes result in transient cognitive impairment. Recurrent seizures, particularly when frequent, can lead to cognitive regression. While the clinical data linking interictal spikes to persistent cognitive impairment is limited, interictal spikes occurring during the formation and stabilization of neuronal circuits likely contribute to aberrant connectivity. There is insufficient clinical literature to indicate whether interictal spikes are more detrimental than seizures during brain development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.