ArticleObesity (Silver Spring, Md.)2015
Increase in visceral fat per se does not induce insulin resistance in the canine model.
Article in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Abdominal visceral to subcutaneous fat distribution in dogs: computed tomography accuracy and factors associated with distribution.BMC veterinary research · 2026Article
- Analysis of insulin resistance using the non-linear homeostatic model assessment index in overweight canines.Veterinary world · 2022Article
- Activation of NPRs and UCP1-independent pathway following CB1R antagonist treatment is associated with adipose tissue beiging in fat-fed male dogs.American journal of physiology. Endocrinology and metabolism · 2019Article
- Insulin Access to Skeletal Muscle is Preserved in Obesity Induced by Polyunsaturated Diet.Obesity (Silver Spring, Md.) · 2018Article
- Mechanisms of improved glucose handling after metabolic surgery: the big 6.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2016Review
- Exenatide Treatment Alone Improves β-Cell Function in a Canine Model of Pre-Diabetes.PloS one · 2016Article
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19 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo determine whether a selective increase of visceral adipose tissue content will result in insulin resistance.
methodsSympathetic denervation of the omental fat was performed under general inhalant anesthesia by injecting 6-hydroxydopamine in the omental fat of lean mongrel dogs (n = 11). In the conscious animal, whole-body insulin sensitivity was assessed by the minimal model (SI ) and the euglycemic hyperinsulinemic clamp (SICLAMP ). Changes in abdominal fat were monitored by magnetic resonance. All assessments were determined before (Wk0) and 2 weeks (Wk2) after denervation. Data are medians (upper and lower interquartile).
resultsDenervation of omental fat resulted in increased percentage (and content) of visceral fat [Wk0: 10.2% (8.5-11.4); Wk2: 12.4% (10.4-13.6); P < 0.01]. Abdominal subcutaneous fat remained unchanged. However, no changes were found in SI [Wk0: 4.7 (mU/l)(-1) min(-1) (3.1-8.8); Wk2: 5.3 (mU/l)(-1) min(-1) (4.5-7.2); P = 0.59] or SICLAMP [Wk0: 42.0 × 10(-4) dl kg(-1) min(-1) (mU/l)(-1) (41.0-51.0); Wk2: 40.0 × 10(-4) dl kg(-1) min(-1) (mU/l) (-1) (34.0-52.0); P = 0.67].
conclusionsDespite a selective increase in visceral adiposity in dogs, insulin sensitivity in vivo did not change, which argues against the concept that accumulation of visceral adipose tissue contributes to insulin resistance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.