ArticleThe Journal of clinical endocrinology and metabolism2014
Comparison of fracture risk prediction by the US Preventive Services Task Force strategy and two alternative strategies in women 50-64 years old in the Women's Health Initiative.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Pooled it
- Pooled it
- Risk Assessment Tools for Osteoporosis Screening in Postmenopausal Women: A Systematic Review.Current osteoporosis reports · 2015Pooled it
- A Comparison of US and Canadian Osteoporosis Screening and Treatment Strategies in Postmenopausal Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Trial
- Associations of Accelerometer-Measured Physical Activity and Sedentary Behavior With Incident Clinical Osteoporotic Fractures Among Older Women: The Objective Physical Activity and Cardiovascular Health Study.Journal of aging and physical activity · 2026Article
- Identifying Younger Postmenopausal Women With Osteoporosis Using USPSTF-Recommended Osteoporosis Risk Assessment Tools.JAMA network open · 2025Article
- A new cut-off value of FRAX tools as an osteoporosis screening tool for Thai geriatric population.Scientific reports · 2025Article
- Bone density and trabecular bone score to predict fractures in adults aged 20-39 years: a registry-based study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Clinical Characteristics of Elderly People with Osteoporotic Vertebral Compression Fracture Based on a 12-Year Single-Center Experience in Korea.Geriatrics (Basel, Switzerland) · 2022Article
- Performance of the Fracture Risk Assessment Tool Associated with Muscle Mass Measurements and Handgrip to Screen for the Risk of Osteoporosis in Young Postmenopausal Women.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Article
- Changing trabecular patterns in panoramic radiographs of Swedish women during 25 years of follow-up.Dento maxillo facial radiology · 2020Article
- Osteoporosis in Polish Older Women: Risk Factors and Osteoporotic Fractures: A Cross-Sectional Study.International journal of environmental research and public health · 2020Article
- Article
- Development of a comprehensive health-risk prediction tool for postmenopausal women.Menopause (New York, N.Y.) · 2019Article
- Association of Physical Activity and Fracture Risk Among Postmenopausal Women.JAMA network open · 2019Article
- Predicting radiological vertebral fractures with a combined physical function and body composition scoring system.Journal of bone and mineral metabolism · 2019Article
- Predicting Fracture Risk in Younger Postmenopausal Women: Comparison of the Garvan and FRAX Risk Calculators in the Women's Health Initiative Study.Journal of general internal medicine · 2019Observational
- Bone Health During the Menopause Transition and Beyond.Obstetrics and gynecology clinics of North America · 2018Review
- Performance of Osteoporosis Self-Assessment Tool (OST) in Predicting Osteoporosis-A Review.International journal of environmental research and public health · 2018Review
- Bone Turnover Markers Are Not Associated With Hip Fracture Risk: A Case-Control Study in the Women's Health Initiative.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
contextThe United States Preventive Services Task Force (USPSTF) recommends osteoporosis screening for women younger than 65 years whose 10-year predicted risk of major osteoporotic fracture (MOF) is at least 9.3% using the Fracture Risk Assessment Tool. In postmenopausal women age 50-64 years old, it is uncertain how the USPSTF screening strategy compares with the Osteoporosis Self-Assessment Tool and the Simple Calculated Osteoporosis Risk Estimate (SCORE) in discriminating women who will and will not experience MOF.
objectiveThis study aimed to assess the sensitivity, specificity, and area under the receiver operating characteristic curve of the three strategies for discrimination of incident MOF over 10 years of follow-up among postmenopausal women age 50-64 years. SETTING AND
designThis was a prospective study conducted between 1993-2008 at 40 US Centers.
participantsWe analyzed data from participants of the Women's Health Initiative Observational Study and Clinical Trials, age 50-64 years, not taking osteoporosis medication (n = 62 492).
main outcome measuresThe main outcome was 10-year (observed) incidence of MOF.
resultsFor identifying women with incident MOF, sensitivity of the strategies ranged from 25.8-39.8%, specificity ranged from 60.7-65.8%, and AUC values ranged from 0.52-0.56. The sensitivity of the USPSTF strategy for identifying incident MOF ranged from 4.7% (3.3-6.0) among women age 50-54 years to 37.3% (35.4-39.1) for women age 60-64 years. Adjusting the thresholds to improve sensitivity resulted in decreased specificity.
conclusionsOur findings do not support use of the USPSTF strategy, Osteoporosis Self-Assessment Tool, or SCORE to identify younger postmenopausal women who are at higher risk of fracture. Our findings suggest that fracture prediction in younger postmenopausal women requires assessment of risk factors not included in currently available strategies.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.