ArticleJournal of biomechanical engineering2014
Numerical simulation of particle transport and deposition in the pulmonary vasculature.
Article in Journal of biomechanical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Rational nanoparticle design: Optimization using insights from experiments and mathematical models.Journal of controlled release : official journal of the Controlled Release Society · 2023Review
- Cell Inertia: Predicting Cell Distributions in Lung Vasculature to Optimize Re-endothelialization.Frontiers in bioengineering and biotechnology · 2022Article
- Targeted pulmonary drug delivery in coronavirus disease (COVID-19) therapy: A patient-specific in silico study based on magnetic nanoparticles-coated microcarriers adhesion.International journal of pharmaceutics · 2021Article
- Computational fluid dynamics for enhanced tracheal bioreactor design and long-segment graft recellularization.Scientific reports · 2021Article
- Multiscale modeling of hemolysis during microfiltration.Microfluidics and nanofluidics · 2020Article
- Targeted Drug Delivery of Microbubble to Arrest Abdominal Aortic Aneurysm Development: A Simulation Study Towards Optimized Microbubble Design.Scientific reports · 2020Article
- Label-free sorting of soft microparticles using a bioinspired synthetic cilia array.Biomicrofluidics · 2018Article
- Modeling thermal inkjet and cell printing process using modified pseudopotential and thermal lattice Boltzmann methods.Physical review. E · 2018Article
- A Cellular Model of Shear-Induced Hemolysis.Artificial organs · 2017Article
- Nanoparticle transport and delivery in a heterogeneous pulmonary vasculature.Journal of biomechanics · 2017Article
- Multiscale Modeling in the Clinic: Drug Design and Development.Annals of biomedical engineering · 2016Review
- Non-affinity factors modulating vascular targeting of nano- and microcarriers.Advanced drug delivery reviews · 2016Review
- Comparison of generic and subject-specific models for simulation of pulmonary perfusion and forced expiration.Interface focus · 2015Article
- Drug carrier interaction with blood: a critical aspect for high-efficient vascular-targeted drug delivery systems.Therapeutic delivery · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To quantify the transport and adhesion of drug particles in a complex vascular environment, computational fluid particle dynamics (CFPD) simulations of blood flow and drug particulate were conducted in three different geometries representing the human lung vasculature for steady and pulsatile flow conditions. A fully developed flow profile was assumed as the inlet velocity, and a lumped mathematical model was used for the calculation of the outlet pressure boundary condition. A receptor-ligand model was used to simulate the particle binding probability. The results indicate that bigger particles have lower deposition fraction due to less chance of successful binding. Realistic unsteady flow significantly accelerates the binding activity over a wide range of particle sizes and also improves the particle deposition fraction in bifurcation regions when comparing with steady flow condition. Furthermore, surface imperfections and geometrical complexity coupled with the pulsatility effect can enhance fluid mixing and accordingly particle binding efficiency. The particle binding density at bifurcation regions increases with generation order and drug carriers are washed away faster in steady flow. Thus, when studying drug delivery mechanism in vitro and in vivo, it is important to take into account blood flow pulsatility in realistic geometry. Moreover, tissues close to bifurcations are more susceptible to deterioration due to higher uptake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.