Evidence map›Paper›PMID 25321950›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2014

Lack of family-based association between common variations in WNK1 and blood pressure level.

Fuqiang Liu, Qiufang Lian, Jie Ren, Keyu Ren, Yang Wang, Dan Wang, Chao Chu, Lan Wang, Tongshuai Guo, Enqi Liu and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Fuqiang LiuDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
Qiufang LianDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
Jie RenDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
Keyu RenDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
Yang WangDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
Dan WangDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
Chao ChuDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
Lan WangDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
Tongshuai GuoDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
Enqi LiuLaboratory Animal Center, Xi'an Jiaotong University School of Medicine, Xi'an, China (mainland).
Jianjun MuDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
Zuyi YuanDepartment of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
First Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWNK1 (With No-lysine Kinase 1) modulates numerous sodium transport-related ion channels involved in regulation of blood pressure. Several studies have indicated associations between the common variants of the WNK1 gene and hypertension or blood pressure levels. However, little data exists on Asian populations and normotensive or pre-hypertensive subjects. Our aim was to detect whether the common variations in the WNK1 gene are potential contributors to individual variations in blood pressure in a family-based sample. MATERIAL AND

methods525 individuals from 116 families were selected from a rural community of Northern China. Five single-nucleotide polymorphisms were selected from the WNK1 gene. Single-marker and haplotype analyses were conducted using the Family-Based Association Test program.

resultsRegretful, no associations for the 5 WNK1 SNPs and the constructed haplotype blocks of WNK1 with blood pressure level reached nominal statistical significance.

conclusionsWe conclude that although multiple candidate genes are involved in development of hypertension, the genetic polymorphism in WNK1 is not a major contributor to the observed variability in blood pressure and familial clustering risk of hypertension.

Indexed as

AdolescentAdultBlood PressureChinaFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedMinor Histocompatibility AntigensProtein Serine-Threonine KinasesWNK Lysine-Deficient Protein Kinase 1Young AdultIntracellular Signaling Peptides and ProteinsMinor Histocompatibility AntigensProtein Serine-Threonine KinasesWNK1 protein, humanWNK Lysine-Deficient Protein Kinase 1

Identifiers

PMID25321950
PMCPMC4211417
OpenAlexW2155369939

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.