Evidence map›Paper›PMID 25321797›Full record

ArticleOptics express2014

X-ray spatial frequency heterodyne imaging of protein-based nanobubble contrast agents.

Danielle Rand, Masaki Uchida, Trevor Douglas, Christoph Rose-Petruck

Abstract read
In one paragraph

Article in Optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Danielle Rand
Masaki Uchida
Trevor Douglas
Christoph Rose-Petruck

Funding

Phage-based targeted imaging probes and their application to vascular diseasesR01EB012027 · NIBIB · TRUSTEES OF INDIANA UNIVERSITY · PI DOUGLAS, TREVOR · 2011 to 2014
$2.6M
NIBIB NIH HHS NIBIBR01-EB012027NIBIB NIH HHS R01 EB012027
6 · The paper itself

Abstract

Spatial Frequency Heterodyne Imaging (SFHI) is a novel x-ray scatter imaging technique that utilizes nanoparticle contrast agents. The enhanced sensitivity of this new technique relative to traditional absorption-based x-ray radiography makes it promising for applications in biomedical and materials imaging. Although previous studies on SFHI have utilized only metal nanoparticle contrast agents, we show that nanomaterials with a much lower electron density are also suitable. We prepared protein-based "nanobubble" contrast agents that are comprised of protein cage architectures filled with gas. Results show that these nanobubbles provide contrast in SFHI comparable to that of gold nanoparticles of similar size.

Indexed as

NanoparticlesNanostructuresParticle SizeContrast MediaDiagnostic ImagingGoldHumansMetal NanoparticlesX-RaysContrast MediaGold

Identifiers

PMID25321797
PMCPMC4247185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.