Evidence map›Paper›PMID 25321637›Full record

ArticleThe American journal of drug and alcohol abuse2015

Butyrylcholinesterase levels and subjective effects of smoked cocaine in healthy cocaine users.

Paula Askalsky, Raj K Kalapatapu, Richard W Foltin, Sandra D Comer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of drug and alcohol abuse, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Paula AskalskyStony Brook School of Medicine , Stony Brook , NY .
Raj K Kalapatapu
Richard W Foltin
Sandra D Comer
Columbia University · USStony Brook School · USUniversity of California, San Francisco · US

Funding

PHARMACOLOGICAL TREATMENT OF MARIJUANA DEPENDENCEP50DA009236 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KLEBER, HERBERT DAVID · 1994 to 2013
$39.4M
Prescription Opioid Effects in Drug and Non-drug AbusersR01DA016759 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI COMER, SANDRA D · 2003 to 2014
$5.0M
Pioglitazone for the Treatment of Opioid and of Nicotine DependenceR01DA031022 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BISAGA, ADAM, COMER, SANDRA D · 2010 to 2013
$3.5M
Translational Approach to Models in RelapseR01DA021319 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI FOLTIN, RICHARD W · 2007 to 2011
$2.2M
Hypocretin Antagonists as a Novel Approach to Medication DevelopmentR01DA029618 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI FOLTIN, RICHARD W · 2011 to 2014
$1.5M
OT-based Cognitive Rehabilitation of Cocaine AbusersK23DA034883 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KALAPATAPU, RAJKUMAR KIRAN · 2013 to 2017
$900k
Clinical and Preclinical Models in Drug Abuse: Training and DevelopmentK05DA031749 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FOLTIN, RICHARD W · 2011 to 2015
$641k
NIDA NIH HHS K05 DA031749NIDA NIH HHS K05DA031749NIDA NIH HHS K23 DA034883NIDA NIH HHS K23DA034883NIDA NIH HHS P50 DA009236NIDA NIH HHS P50DA09236NIDA NIH HHS R01 DA016759NIDA NIH HHS R01DA016759NIDA NIH HHS R01 DA021319NIDA NIH HHS R01DA021319NIDA NIH HHS R01 DA029618NIDA NIH HHS R01DA029618NIDA NIH HHS R01 DA031022NIDA NIH HHS R01DA031022
6 · The paper itself

Abstract

backgroundButyrylcholinesterase (BChE) is beginning to attract attention as a possible target for cocaine abuse treatment because of its role in metabolizing cocaine.

objectiveThe purpose of this analysis was to assess whether endogenous BChE levels are associated with the subjective effects of cocaine.

methodsData from 28 participants in five inpatient cocaine self-administration studies were included in the present analysis. Four minutes after each smoked cocaine dose, participants rated their drug-related effects from 0-100 using a computerized self-report Visual Analogue Scale (VAS). The main outcome measures were nine change-in-VAS ratings between a baseline placebo dose and a 25-mg smoked cocaine dose.

resultsAfter controlling for age, sex, total years of cocaine use, total milligrams of cocaine administered before the 25-mg dose being analyzed, and baseline diastolic blood pressure, endogenous BChE was not significantly associated with any of the nine change-in-VAS ratings.

conclusionThough BChE appears to be a possible target for cocaine abuse treatment, these data suggest that endogenous levels of BChE may not play a role in modifying the subjective effects of cocaine. Future larger studies of BChE in respect to the subjective effects produced by cocaine are needed to confirm or refute these findings.

Indexed as

Administration, InhalationAdultBlood PressureButyrylcholinesteraseCocaineCocaine-Related DisordersDrug UsersFemaleHumansMaleMiddle AgedButyrylcholinesteraseCocaineButyrylcholinesterasecocainepseudocholinesterasesubjective effects

Identifiers

PMID25321637
PMCPMC4336628
OpenAlexW1977860725

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.