Evidence map›Paper›PMID 25321479›Full record

ArticleCell death & disease2014

Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development.

N M Martin-Blanco, S Checquolo, F Del Gaudio, R Palermo, G Franciosa, L Di Marcotullio, A Gulino, M Canelles, I Screpanti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

N M Martin-BlancoDepartment of Molecular Medicine, Sapienza University, 00161 Rome, Italy.
S ChecquoloDepartment of Medico-Surgical Sciences and Biotechnology, Sapienza University, Latina 04100, Italy.
F Del GaudioDepartment of Molecular Medicine, Sapienza University, 00161 Rome, Italy.
R PalermoCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome 00161, Italy.
G FranciosaDepartment of Molecular Medicine, Sapienza University, 00161 Rome, Italy.
L Di MarcotullioDepartment of Molecular Medicine, Sapienza University, 00161 Rome, Italy.
A Gulino1] Department of Molecular Medicine, Sapienza University, 00161 Rome, Italy [2] Neuromed Institute, Pozzilli 86007, Italy.
M CanellesInstitute of Parasitology and Biomedicine 'Lopez Neyra', Spanish National Research Council, Granada 18100, Spain.
I Screpanti1] Department of Molecular Medicine, Sapienza University, 00161 Rome, Italy [2] Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome 00161, Italy [3] Institut Pasteur-Foundation Cenci Bolognetti, Sapienza University, Rome 00161, Italy.
Sapienza University of Rome · ITItalian Institute of Technology · ITInstituto de Parasitología y Biomedicina "López - Neyra" · ESIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numb asymmetrically segregates at mitosis to control cell fate choices during development. Numb inheritance specifies progenitor over differentiated cell fates, and, paradoxically, also promotes neuronal differentiation, thus indicating that the role of Numb may change during development. Here we report that Numb nuclear localization is restricted to early thymocyte precursors, whereas timed appearance of pre-T-cell receptor (pre-TCR) and activation of protein kinase Cθ promote phosphorylation-dependent Numb nuclear exclusion. Notably, nuclear localization of Numb in early thymocyte precursors favors p53 nuclear stabilization, whereas pre-TCR-dependent Numb nuclear exclusion promotes the p53 downmodulation essential for further differentiation. Accordingly, the persistence of Numb in the nucleus impairs the differentiation and promotes precursor cell death. This study reveals a novel regulatory mechanism for Numb function based on its nucleus-cytosol shuttling, coupling the different roles of Numb with different stages of T-cell development.

Indexed as

Active Transport, Cell NucleusAnimalsCell DeathCell DifferentiationCell NucleusHEK293 CellsHumansIsoenzymesMembrane ProteinsMiceModels, BiologicalNerve Tissue ProteinsPhosphorylationPrecursor Cells, T-LymphoidProteasome Endopeptidase ComplexProtein Kinase CIsoenzymesMembrane ProteinsNerve Tissue ProteinsNumb protein, mousePrkcq protein, mouseProteasome Endopeptidase ComplexProtein Kinase CProtein Kinase C-thetaReceptors, Antigen, T-CellTumor Suppressor Protein p53

Identifiers

PMID25321479
PMCPMC4237259
OpenAlexW2010146593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.