ReviewClinical and molecular hepatology2014
Factors affecting drug-induced liver injury: antithyroid drugs as instances.
Review in Clinical and molecular hepatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- 10.6 μm laser moxibustion can improve oxidative stress and abnormal energy metabolism in liver of hypothyroidism rats through Nrf2/HO-1 and Nrf2/PGC-1α/TFAM pathways.Lasers in medical science · 2026Article
- Drug-induced liver injury due to potassium iodide during thyroid storm.JCEM case reports · 2026Article
- Interplay between endocrine disorders and liver dysfunction: Mechanisms of damage and therapeutic approaches.World journal of gastroenterology · 2025Review
- Risk factors and a nomogram for predicting valproic acid-induced liver injury : A nested case-control study.Biomolecules & biomedicine · 2025Article
- Methimazole-induced cholestasis initially obscured by an incidental finding of a large periampullary diverticulum: A case report with reference to the updated RUCAM of 2016.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Unusual Management of a Rare Case of Methimazole-Resistant Graves Disease.JCEM case reports · 2025Article
- Propylthiouracil-induced ANCA-associated vasculitis complicated by granulocytopenia and hemophagocytosis: a case report.Frontiers in medicine · 2025Article
- Clinical Characteristics and Outcomes of Patients With Antithyroid Drug-Related Liver Injury.Journal of the Endocrine Society · 2023Review
- Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence.Heliyon · 2023Article
- Identification of Drug-Induced Liver Injury Biomarkers from Multiple Microarrays Based on Machine Learning and Bioinformatics Analysis.International journal of molecular sciences · 2022Article
- Protective Effect of Natural Antioxidant Compounds on Methimazole Induced Oxidative Stress in a Feline Kidney Epithelial Cell Line (CRFK).Veterinary sciences · 2021Article
- Management of Feline Hyperthyroidism and the Need to Prevent Oxidative Stress: What Can We Learn from Human Research?Antioxidants (Basel, Switzerland) · 2021Review
- [The thyroid gland in old age : Physiology and pathology].Wiener medizinische Wochenschrift (1946) · 2020Article
- Evaluation of Antioxidant Supplementation on Redox Unbalance in Hyperthyroid Cats Treated with Methimazole: A Blinded Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2019Article
- Redox unbalance in the hyperthyroid cat: a comparison with healthy and non-thyroidal diseased cats.BMC veterinary research · 2019Article
- Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives.BioMed research international · 2019Review
- Hepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies.Endocrinology, diabetes & metabolism case reports · 2018Article
- Methimazole-induced liver injury overshadowed by methylprednisolone pulse therapy: Case report.Medicine · 2017Article
- Incidence of abnormal liver biochemical tests in hyperthyroidism.Clinical endocrinology · 2017Article
- The Opportunities of Metabolomics in Drug Safety Evaluation.Current pharmacology reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for predicting the occurrence of hepatotoxicity induced by these drugs. The purpose of this article is to give an overview on possible susceptibility factors in liver injury induced by antithyroid agents. Age, gender, metabolism characteristics, alcohol consumption, underlying diseases, immunologic mechanisms, and drug interactions are involved in enhancing antithyroid drugs-induced hepatic damage. An outline on the clinically used treatments for antithyroid drugs-induced hepatotoxicity and the potential therapeutic strategies found to be effective against this complication are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.