ArticleAfrican health sciences2014
Nodding syndrome in Tanzania may not be associated with circulating anti-NMDA-and anti-VGKC receptor antibodies or decreased pyridoxal phosphate serum levels-a pilot study.
Article in African health sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Nodding syndrome: A key role for sources of nutrition?eNeurologicalSci · 2022Review
- Nodding Syndrome: A Scoping Review.Tropical medicine and infectious disease · 2021Article
- Article
- Nodding syndrome: a concise review.Brain communications · 2020Review
- Neurological manifestations in Onchocerca volvulus infection: A review.Brain research bulletin · 2019Review
- Unravelling the mysterious onchocerciasis-nodding syndrome link: new developments and future challenges.Annals of translational medicine · 2017Article
- Nodding syndrome may be an autoimmune reaction to the parasitic wormScience translational medicine · 2017Article
- Nodding syndrome and epilepsy in onchocerciasis endemic regions: comparing preliminary observations from South Sudan and the Democratic Republic of the Congo with data from Uganda.BMC research notes · 2016Article
- Nodding Syndrome May Be Only the Ears of the Hippo.PLoS neglected tropical diseases · 2015Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNodding syndrome (NS) is a seemingly progressive epilepsy disorder of unknown underlying cause. We investigated association of pyridoxal-phosphate serum levels and occurrence of anti-neuronal antibodies against N-methyl-D-aspartate (NMDA) receptor and voltage gated potassium channel (VGKC) complex in NS patients.
methodsSera of a Tanzanian cohort of epilepsy and NS patients and community controls were tested for the presence of anti-NMDA-receptor and anti-VGKC complex antibodies by indirect immunofluorescence assay. Furthermore pyridoxal-phosphate levels were measured.
resultsAuto-antibodies against NMDA receptor or VGKC (LG1 or Caspr2) complex were not detected in sera of patients suffering from NS (n=6), NS plus other seizure types (n=16), primary generalized epilepsy (n=1) and community controls without epilepsy (n=7). Median Pyridoxal-phosphate levels in patients with NS compared to patients with primary generalized seizures and community controls were not significantly different. However, these median pyridoxal-phosphate levels are significantly lower compared to the range considered normal in Europeans.
conclusionsIn this pilot study NS was not associated with serum anti-NMDA receptor or anti-VGKC complex antibodies and no association to pyridoxal-phosphate serum levels was found.
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