Evidence map›Paper›PMID 25320523›Full record

ReviewWorld journal of gastroenterology2014

Treatment of severe acute pancreatitis and its complications.

Enver Zerem

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02648815 (Management of Moderate and Severe Forms of Acute Pancreatitis), which is not on this map. Cited by 177 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 6 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02648815 naunknown statusnot on this map

Management of Moderate and Severe Forms of Acute Pancreatitis

TypeinterventionalSponsorUniversity Clinical Center TuzlaRan2010 to 2017Enrolled100ConditionsPancreatitisArmsPercutaneous catheter drainage, Abdominal paracentesis evacuation
3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 6 syntheses or guidelines pooled it, 352 citations in OpenAlex.

  1. Pooled it
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  7. Trial
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  15. Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026
    Review
  16. Review
  17. Article
  18. Research Progress onMediators of inflammation · 2026
    Review
  19. Review
  20. Review

117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Enver ZeremEnver Zerem, Department of Gastroenterology, University Clinical Center Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
University of Tuzla · BA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute pancreatitis (SAP), which is the most serious type of this disorder, is associated with high morbidity and mortality. SAP runs a biphasic course. During the first 1-2 wk, a pro-inflammatory response results in systemic inflammatory response syndrome (SIRS). If the SIRS is severe, it can lead to early multisystem organ failure (MOF). After the first 1-2 wk, a transition from a pro-inflammatory response to an anti-inflammatory response occurs; during this transition, the patient is at risk for intestinal flora translocation and the development of secondary infection of the necrotic tissue, which can result in sepsis and late MOF. Many recommendations have been made regarding SAP management and its complications. However, despite the reduction in overall mortality in the last decade, SAP is still associated with high mortality. In the majority of cases, sterile necrosis should be managed conservatively, whereas in infected necrotizing pancreatitis, the infected non-vital solid tissue should be removed to control the sepsis. Intervention should be delayed for as long as possible to allow better demarcation and liquefaction of the necrosis. Currently, the step-up approach (delay, drain, and debride) may be considered as the reference standard intervention for this disorder.

Indexed as

Disease ProgressionHumansInflammation MediatorsPancreatitisPancreatitis, Acute NecrotizingSeverity of Illness IndexTreatment OutcomeInflammation MediatorsAcute necrotizing pancreatitisDrainageGastrointestinal endoscopyInfectionSepsis

Identifiers

PMID25320523
PMCPMC4194569
OpenAlexW2028556625

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.