Evidence map›Paper›PMID 25320521›Full record

ReviewWorld journal of gastroenterology2014

Gastric cancer: prevention, screening and early diagnosis.

Victor Pasechnikov, Sergej Chukov, Evgeny Fedorov, Ilze Kikuste, Marcis Leja

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06342427 (Early Detection of Stomach Cancer With a Liquid Biopsy Based on Exosomal Micro-RNA), which is not on this map. Cited by 236 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06342427 completednot on this mapstarted 2023, after this paper: background citation

Early Detection of Stomach Cancer With a Liquid Biopsy Based on Exosomal Micro-RNA

TypeobservationalSponsorCity of Hope Medical CenterRan2023 to 2024Enrolled809ConditionsGastric Cancer, Gastric Adenocarcinoma, Gastric Cancer Stage, Gastric NeoplasmArmsDESTINEX
3 · Its place in the literature

Who cites it

236 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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176 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Victor PasechnikovVictor Pasechnikov, Sergej Chukov, Stavropol State Medical University, 355017 Stavropol, Russia.
Sergej ChukovVictor Pasechnikov, Sergej Chukov, Stavropol State Medical University, 355017 Stavropol, Russia.
Evgeny FedorovVictor Pasechnikov, Sergej Chukov, Stavropol State Medical University, 355017 Stavropol, Russia.
Ilze KikusteVictor Pasechnikov, Sergej Chukov, Stavropol State Medical University, 355017 Stavropol, Russia.
Marcis LejaVictor Pasechnikov, Sergej Chukov, Stavropol State Medical University, 355017 Stavropol, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer continues to be an important healthcare problem from a global perspective. Most of the cases in the Western world are diagnosed at late stages when the treatment is largely ineffective. Helicobacter pylori (H. pylori) infection is a well-established carcinogen for gastric cancer. While lifestyle factors are important, the efficacy of interventions in their modification, as in the use of antioxidant supplements, is unconvincing. No organized screening programs can be found outside Asia (Japan and South Korea). Although several screening approaches have been proposed, including indirect atrophy detection by measuring pepsinogen in the circulation, none of them have so far been implemented, and more study data is required to justify any implementation. Mass eradication of H. pylori in high-risk areas tends to be cost-effective, but its adverse effects and resistance remain a concern. Searches for new screening biomarkers, including microRNA and cancer-autoantibody panels, as well as detection of volatile organic compounds in the breath, are in progress. Endoscopy with a proper biopsy follow-up remains the standard for early detection of cancer and related premalignant lesions. At the same time, new advanced high-resolution endoscopic technologies are showing promising results with respect to diagnosing mucosal lesions visually and targeting each biopsy. New histological risk stratifications (classifications), including OLGA and OLGIM, have recently been developed. This review addresses the current means for gastric cancer primary and secondary prevention, the available and emerging methods for screening, and new developments in endoscopic detection of early lesions of the stomach.

Indexed as

Early Detection of CancerBiopsyGastroscopyHumansLife StyleNeoplasm StagingPrecancerous ConditionsPredictive Value of TestsPreventive Health ServicesRisk AssessmentRisk FactorsRisk Reduction BehaviorStomach NeoplasmsGastric cancerHelicobacter pylori

Identifiers

PMID25320521
PMCPMC4194567

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.