Evidence map›Paper›PMID 25320456›Full record

ArticleJournal of clinical biochemistry and nutrition2014

Antidiabetic effect of the α-lipoic acid γ-cyclodextrin complex.

Yuki Naito, Naoko Ikuta, Daisuke Nakata, Keiji Terao, Kinuyo Matsumoto, Naemi Kajiwara, Ayaka Okano, Hiroyuki Yasui, Yutaka Yoshikawa

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yuki NaitoDepartment of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5, Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan.
Naoko IkutaDepartment of Social/Community Medicine and Health Science, Food and Drug Evaluation Science, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Daisuke NakataCycloChem Bio Co., Ltd., KIBC 654R, 5-5-2, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Keiji TeraoDepartment of Social/Community Medicine and Health Science, Food and Drug Evaluation Science, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan ; CycloChem Bio Co., Ltd., KIBC 654R, 5-5-2, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Kinuyo MatsumotoDepartment of Health and Sports Nutrition, Faculty of Health and Welfare, Kobe Women's University, 4-7-2, Minatojima-Nakamachi, Chuo-ku, Kobe 650-0046, Japan.
Naemi KajiwaraDepartment of Health and Sports Nutrition, Faculty of Health and Welfare, Kobe Women's University, 4-7-2, Minatojima-Nakamachi, Chuo-ku, Kobe 650-0046, Japan.
Ayaka OkanoDepartment of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5, Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan.
Hiroyuki YasuiDepartment of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5, Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan.
Yutaka YoshikawaDepartment of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5, Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan ; Department of Health and Sports Nutrition, Faculty of Health and Welfare, Kobe Women's University, 4-7-2, Minatojima-Nakamachi, Chuo-ku, Kobe 650-0046, Japan.
Kobe Women's University · JPKyoto Pharmaceutical University · JPKobe University · JPInstitute of Bioorganic Chemistry · BY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the number of patients suffering from diabetes mellitus has been increasing worldwide. In particular, type 2 diabetes mellitus, a lifestyle-related disease, is recognized as a serious disease with various complications. Many types of pharmaceutics or specific health foods have been used for the management of diabetes mellitus. At the same time, the relationship between diabetes mellitus and α-lipoic acid has been recognized for many years. In this study, we found that the α-lipoic acid γ-cyclodextrin complex exhibited an HbA1c lowering effect for treating type 2 diabetes mellitus in animal models. Moreover, in this study, we investigated the activation of phosphorylation of AMP-activated protein kinase, which plays a role in cellular energy homeostasis, in the liver of KKA(y) mice by using α-lipoic acid and the α-lipoic acid γ-cyclodextrin complex. Our results show that the α-lipoic acid γ-cyclodextrin complex strongly induced the phosphorylation of AMP-activated protein kinase. Thus, we concluded that intake of the α-lipoic acid γ-cyclodextrin complex exerted an antidiabetic effect by suppressing the elevation of postprandial hyperglycemia as well as doing exercise.

Indexed as

antidiabetic effecttype 2 diabetes mellitusα-lipoic acidγCD complex

Identifiers

PMID25320456
PMCPMC4186374
OpenAlexW2094488777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.