ArticleJournal of virology2015
Complex T-cell receptor repertoire dynamics underlie the CD8+ T-cell response to HIV-1.
Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Medical software for precision diagnostics of infection with immunoprofiling and artificial intelligence.Journal of translational medicine · 2026Review
- A comprehensive model based on temporal dynamics of peripheral T cell repertoire for predicting post-treatment distant metastasis of nasopharyngeal carcinoma.Cancer immunology, immunotherapy : CII · 2022Article
- Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy.Frontiers in immunology · 2022Article
- Article
- T-cell receptor repertoire of cytomegalovirus-specific cytotoxic T-cells after allogeneic stem cell transplantation.Scientific reports · 2020Article
- Review
- Article
- BKV Clearance Time Correlates With Exhaustion State and T-Cell Receptor Repertoire Shape of BKV-Specific T-Cells in Renal Transplant Patients.Frontiers in immunology · 2019Article
- Detection of Enriched T Cell Epitope Specificity in Full T Cell Receptor Sequence Repertoires.Frontiers in immunology · 2019Article
- On the feasibility of mining CD8+ T cell receptor patterns underlying immunogenic peptide recognition.Immunogenetics · 2018Article
- Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8Nature structural & molecular biology · 2017Article
- HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- High-Throughput Sequencing-Based Immune Repertoire Study during Infectious Disease.Frontiers in immunology · 2016Review
- CD8+ TCR Bias and Immunodominance in HIV-1 Infection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
unlabelledAlthough CD8(+) T cells are important for the control of HIV-1 in vivo, the precise correlates of immune efficacy remain unclear. In this study, we conducted a comprehensive analysis of viral sequence variation and T-cell receptor (TCR) repertoire composition across multiple epitope specificities in a group of antiretroviral treatment-naive individuals chronically infected with HIV-1. A negative correlation was detected between changes in antigen-specific TCR repertoire diversity and CD8(+) T-cell response magnitude, reflecting clonotypic expansions and contractions related to alterations in cognate viral epitope sequences. These patterns were independent of the individual, as evidenced by discordant clonotype-specific transitions directed against different epitopes in single subjects. Moreover, long-term asymptomatic HIV-1 infection was characterized by evolution of the TCR repertoire in parallel with viral replication. Collectively, these data suggest a continuous bidirectional process of adaptation between HIV-1 and virus-specific CD8(+) T-cell clonotypes orchestrated at the TCR-antigen interface. IMPORTANCE: We describe a relation between viral epitope mutation, antigen-specific T-cell expansion, and the repertoire of responding clonotypes in chronic HIV-1 infection. This work provides insights into the process of coadaptation between the human immune system and a rapidly evolving lentivirus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.