ArticleJournal of clinical microbiology2014
Multilocus sequence typing of Corynebacterium ulcerans provides evidence for zoonotic transmission and for increased prevalence of certain sequence types among toxigenic strains.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Detection and diphtheria toxin status of Corynebacterium ulcerans in canine and feline clinical specimens in Japan.The Journal of veterinary medical science · 2026Article
- Toxigenic Corynebacterium ulcerans in raw milk of a cow with acute mastitis: case report and historical review on milk-transmitted diphtheria.Infection · 2025Review
- Microevolution and genomic epidemiology of the diphtheria-causing zoonotic pathogen Corynebacterium ulcerans.Nature communications · 2025Article
- Article
- Zoonotic Transmission of Diphtheria from Domestic Animal Reservoir, Spain.Emerging infectious diseases · 2022Article
- Molecular Characterization ofVeterinary sciences · 2021Article
- Limitations of Ribotyping as Genotyping Method for Corynebacterium ulcerans.Emerging infectious diseases · 2020Article
- ST534: the new sequence type of Corynebacterium diphtheriae causing diphtheria in Jakarta and surrounding areas, IndonesiaTurkish journal of medical sciences · 2020Article
- Article
- Population Gene Introgression and High Genome Plasticity for the Zoonotic Pathogen Streptococcus agalactiae.Molecular biology and evolution · 2019Article
- Tox-positive Corynebacterium ulcerans in hedgehogs, GermanyEmerging microbes & infections · 2019Article
- A case of cutaneous toxigenicAccess microbiology · 2019Article
- Genomic analyses reveal two distinct lineages ofNew microbes and new infections · 2018Article
- Geographically Diverse Clusters of Nontoxigenic Corynebacterium diphtheriae Infection, Germany, 2016-2017.Emerging infectious diseases · 2018Article
- Non-toxigenic Corynebacterium ulcerans sequence types 325 and 339 isolated from two dogs with ulcerative lesions in Italy.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018Article
- Isolation and characterization of Corynebacterium spp. from bulk tank raw cow's milk of different dairy farms in Germany.PloS one · 2018Article
- Respiratory diphtheria due to Corynebacterium ulcerans transmitted by a companion dog, Italy 2014.Infection · 2017Article
- Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island.Genome medicine · 2014Article
- Transmission of toxigenicAcute medicine & surgeryArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human-to-human-transmitted Corynebacterium diphtheriae was historically the main pathogen causing diphtheria and has therefore been studied extensively in the past. More recently, diphtheria caused by toxigenic Corynebacterium ulcerans is an emerging disease in several industrial countries, including the United Kingdom, the United States, France, and Germany. However, toxigenic C. ulcerans has so far been almost neglected in the development of epidemiologic tools. One of the most important tools in modern epidemiology to understand transmission pathways is sequence typing of pathogens. Here, we provide a protocol for multilocus sequence typing (MLST) to type C. ulcerans strains rapidly and relatively cost-effectively. Applying MLST to C. ulcerans for the first time, we show that related sequence types (STs) might be associated with the presence of the diphtheria toxin gene, which encodes diphtheria toxin (DT), the most important diphtheria-causing virulence factor. Interestingly, we found only two very closely related STs in the isolates derived from six dogs. Additionally, our data show that all STs derived from animals which were at least twice present in our analysis were found in humans as well. This finding is congruent with zoonotic transmission of C. ulcerans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.