Evidence map›Paper›PMID 25320223›Full record

ArticleThe Journal of rheumatology2014

Hospitalized infections in giant cell arteritis: a population-based retrospective cohort study.

Prabhu D Udayakumar, Arun K Chandran, Cynthia S Crowson, Kenneth J Warrington, Eric L Matteson

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in The Journal of rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Morbidity and Mortality of Large-Vessel Vasculitides.Current rheumatology reports · 2020
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Prabhu D UdayakumarFrom the Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.P.D. Udayakumar, MD; A.K. Chandran, MBBS; C.S. Crowson, MS; K.J. Warrington, MD; E.L. Matteson, MD, MPH, Division of Rheumatology, Mayo Clinic College of Medicine. udaya009@umn.edu.
Arun K ChandranFrom the Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.P.D. Udayakumar, MD; A.K. Chandran, MBBS; C.S. Crowson, MS; K.J. Warrington, MD; E.L. Matteson, MD, MPH, Division of Rheumatology, Mayo Clinic College of Medicine.
Cynthia S CrowsonFrom the Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.P.D. Udayakumar, MD; A.K. Chandran, MBBS; C.S. Crowson, MS; K.J. Warrington, MD; E.L. Matteson, MD, MPH, Division of Rheumatology, Mayo Clinic College of Medicine.
Kenneth J WarringtonFrom the Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.P.D. Udayakumar, MD; A.K. Chandran, MBBS; C.S. Crowson, MS; K.J. Warrington, MD; E.L. Matteson, MD, MPH, Division of Rheumatology, Mayo Clinic College of Medicine.
Eric L MattesonFrom the Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.P.D. Udayakumar, MD; A.K. Chandran, MBBS; C.S. Crowson, MS; K.J. Warrington, MD; E.L. Matteson, MD, MPH, Division of Rheumatology, Mayo Clinic College of Medicine.
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
NCATS NIH HHS UL1 TR000135NIA NIH HHS R01 AG034676NIA NIH HHS R01AG034676
6 · The paper itself

Abstract

objectiveTo assess the occurrence of infections requiring or acquired during hospitalization in patients with giant cell arteritis (GCA).

methodsWe retrospectively reviewed a population-based incidence cohort of patients with GCA diagnosed between 1950 and 2009 and compared this cohort with a non-GCA one matched for age, sex, and calendar year from the same population.

resultsWe identified 245 patients in the GCA cohort and 245 patients in the non-GCA cohort. Seventy-four GCA subjects (134 episodes) and 79 non-GCA (153 episodes) had infections requiring or acquired during hospitalization [rate ratio (RR) 0.94; 95% CI 0.74, 1.18]. Sixty-seven subjects (107 episodes) in the GCA cohort and 63 subjects (110 episodes) in non-GCA cohort required hospitalization secondary to an infection (RR 1.04; CI 0.80, 1.36). Pneumonia, urinary tract infections (UTI), skin and soft tissue infections accounted for the majority of infections requiring hospitalization and had similar occurrence in both cohorts. UTI accounted for the majority of infections requiring hospitalization in the first 6 months after GCA incidence (RR 3.93; CI 0.85, 56.52). No difference between the 2 cohorts was noted in overall infections acquired during hospitalization (RR 0.68; CI 0.41, 1.08).

conclusionThere is no overall increased risk of infections requiring or acquired during hospitalization in patients with GCA who are taking glucocorticoid therapy. There may be an increased risk of infections requiring hospitalization, especially of the urinary tract, in the first 6 months after GCA incidence, although this did not achieve statistical significance in our study.

Indexed as

AgedAged, 80 and overCohort StudiesCommunity-Acquired InfectionsCross InfectionFemaleGiant Cell ArteritisGlucocorticoidsHospitalizationHumansIncidenceMalePneumoniaRetrospective StudiesRisk FactorsSkin Diseases, InfectiousGlucocorticoidsCOHORT STUDIESGIANT CELL ARTERITISHOSPITALIZATIONINFECTION

Identifiers

PMID25320223
PMCPMC4254117
OpenAlexW2159499015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.