ArticleThe Journal of biological chemistry2014
A novel class of somatic small RNAs similar to germ cell pachytene PIWI-interacting small RNAs.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Conserved enhancer association of piRNAs and the implication in germ cell fate surveillance.Genome biology · 2026Article
- Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines.Signal transduction and targeted therapy · 2025Review
- Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer.Frontiers in molecular biosciences · 2023Review
- Unraveling mitochondrial piRNAs in mouse embryonic gonadal cells.Scientific reports · 2022Article
- piRNAQuest V.2: an updated resource for searching through the piRNAome of multiple species.RNA biology · 2022Article
- PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation.Cell reports · 2021Article
- Dynamics of cattle sperm sncRNAs during maturation, from testis to ejaculated sperm.Epigenetics & chromatin · 2021Article
- Somatic expression of piRNA and associated machinery in the mouse identifies short, tissue-specific piRNA.Epigenetics · 2019Article
- Genome sequencing analysis of blood cells identifies germline haplotypes strongly associated with drug resistance in osteosarcoma patients.BMC cancer · 2019Article
- The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing.PLoS genetics · 2019Article
- piRDisease v1.0: a manually curated database for piRNA associated diseases.Database : the journal of biological databases and curation · 2019Article
- Bioimaging of multiple piRNAs in a single breast cancer cell using molecular beacons.MedChemComm · 2017Article
- The roles of non-coding RNAs in cardiac regenerative medicine.Non-coding RNA research · 2017Review
- Paternal pachytene piRNAs are not required for fertilization, embryonic development and sperm-mediated epigenetic inheritance in mice.Environmental epigenetics · 2016Article
- SpermBase: A Database for Sperm-Borne RNA Contents.Biology of reproduction · 2016Article
- Genome-wide differential expression of genes and small RNAs in testis of two different porcine breeds and at two different ages.Scientific reports · 2016Article
- piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals.RNA (New York, N.Y.) · 2015Article
- Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology.Scientific reports · 2015Article
- Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs.Environmental epigeneticsArticle
- Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
PIWI-interacting RNAs (piRNAs) are small noncoding RNAs that bind PIWI family proteins exclusively expressed in the germ cells of mammalian gonads. MIWI2-associated piRNAs are essential for silencing transposons during primordial germ cell development, and MIWI-bound piRNAs are required for normal spermatogenesis during adulthood in mice. Although piRNAs have long been regarded as germ cell-specific, increasing lines of evidence suggest that somatic cells also express piRNA-like RNAs (pilRNAs). Here, we report the detection of abundant pilRNAs in somatic cells, which are similar to MIWI-associated piRNAs mainly expressed in pachytene spermatocytes and round spermatids in the testis. Based on small RNA deep sequencing and quantitative PCR analyses, pilRNA expression is dynamic and displays tissue specificity. Although pilRNAs are similar to pachytene piRNAs in both size and genomic origins, they have a distinct ping-pong signature. Furthermore, pilRNA biogenesis appears to utilize a yet to be identified pathway, which is different from all currently known small RNA biogenetic pathways. In addition, pilRNAs appear to preferentially target the 3'-UTRs of mRNAs in a partially complementary manner. Our data suggest that pilRNAs, as an integral component of the small RNA transcriptome in somatic cell lineages, represent a distinct population of small RNAs that may have functions similar to germ cell piRNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.