ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Sensory and motor peripheral nerve function and longitudinal changes in quadriceps strength.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Dose-Response Relationships of Resistance Training in Healthy Old Adults: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- Sensory impairment, epigenetic ageing, and later-life functional decline and mortality in older adults.GeroScience · 2026Article
- EMG-Based Simulation for Optimization of Human-in-the-Loop Control in Simple Robotic Walking Assistance.Journal of sensor and actuator networks · 2025Article
- Frailty and peripheral neuropathy in hemodialysis patients: clinical and electrophysiological correlations.Renal failure · 2025Article
- Lower Leg Power and Grip Strength Are Associated With Increased Fall Injury Risk in Older Men: The Osteoporotic Fractures in Men Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Associations of Lower Extremity Peripheral Nerve Impairment and Risk of Dementia in Black and White Older Adults.Neurology · 2022Article
- Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction.Aging and disease · 2021Review
- Jump power, leg press power, leg strength and grip strength differentially associated with physical performance: The Developmental Epidemiologic Cohort Study (DECOS).Experimental gerontology · 2021Article
- Sarcopenia: What Is the Origin of This Aging-Induced Disorder?Frontiers in genetics · 2021Review
- Article
- Multiple Sensory Impairment Is Associated With Increased Risk of Dementia Among Black and White Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Chronic kidney disease and peripheral nerve function in the Health, Aging and Body Composition Study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Article
- Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle.Antioxidants & redox signaling · 2018Article
- Redox homeostasis and age-related deficits in neuromuscular integrity and function.Journal of cachexia, sarcopenia and muscle · 2017Review
- Relationship between sensorimotor peripheral nerve function and indicators of cardiovascular autonomic function in older adults from the Health, Aging and Body Composition Study.Experimental gerontology · 2017Article
- Physical Training and Activity in People With Diabetic Peripheral Neuropathy: Paradigm Shift.Physical therapy · 2017Review
- Article
- Sensorimotor Peripheral Nerve Function and Physical Activity in Older Men.Journal of aging and physical activity · 2016Article
- Metabolic Syndrome Components Are Associated With Symptomatic Polyneuropathy Independent of Glycemic Status.Diabetes care · 2016Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundPoor peripheral nerve function is common in older adults and may be a risk factor for strength decline, although this has not been assessed longitudinally.
methodsWe assessed whether sensorimotor peripheral nerve function predicts strength longitudinally in 1,830 participants (age = 76.3 ± 2.8, body mass index = 27.2 ± 4.6kg/m(2), strength = 96.3 ± 34.7 Nm, 51.0% female, 34.8% black) from the Health ABC study. Isokinetic quadriceps strength was measured semiannually over 6 years. Peroneal motor nerve conduction amplitude and velocity were recorded. Sensory nerve function was assessed with 10-g and 1.4-g monofilaments and average vibration detection threshold at the toe. Lower-extremity neuropathy symptoms were self-reported.
resultsWorse vibration detection threshold predicted 2.4% lower strength in men and worse motor amplitude and two symptoms predicted 2.5% and 8.1% lower strength, respectively, in women. Initial 10-g monofilament insensitivity predicted 14.2% lower strength and faster strength decline in women and 6.6% lower strength in men (all p < .05).
conclusionPoor nerve function predicted lower strength and faster strength decline. Future work should examine interventions aimed at preventing declines in strength in older adults with impaired nerve function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.