ArticleBMJ open2014
HIV virological failure and drug resistance among injecting drug users receiving first-line ART in China.
Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- What leads to treatment failure among people living with HIV: first systematic review from the middle east and North Africa.Virology journal · 2025Pooled it
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- Failure to Attain HIV Viral Suppression After Intensified Adherence Counselling-What Can We Learn About Its Factors?Infection and drug resistance · 2023Article
- Incorporating social determinants of health into the mathematical modeling of HIV/AIDS.Scientific reports · 2022Review
- Survey of pretreatment HIV drug resistance and the genetic transmission networks among HIV-positive individuals in southwestern China, 2014-2020.BMC infectious diseases · 2021Article
- HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia-Pacific region: a longitudinal cohort study.Journal of the International AIDS Society · 2021Observational
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- Pretreatment HIV drug resistance in adults initiating antiretroviral therapy in China, 2017.Infectious diseases of poverty · 2020Article
- Predictors of virological treatment failure among adult HIV patients on first-line antiretroviral therapy in Woldia and Dessie hospitals, Northeast Ethiopia: a case-control study.BMC infectious diseases · 2019Article
- Immunological and virologic outcomes of people living with HIV in Guangxi, China: 2012-2017.PloS one · 2019Article
- HIV virologic failure and its predictors among HIV-infected adults on antiretroviral therapy in the African Cohort Study.PloS one · 2019Article
- Article
- Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran.Iranian journal of public health · 2017Article
- Mortality and virological failure among HIV-infected people who inject drugs on antiretroviral treatment in China: An observational cohort study.Drug and alcohol dependence · 2017Observational
- Determinants of virological failure among patients on highly active antiretroviral therapy in University of Gondar Referral Hospital, Northwest Ethiopia: a case-control study.HIV/AIDS (Auckland, N.Z.) · 2017Article
- Long-term outcomes of second-line antiretroviral treatment in an adult and adolescent cohort in Myanmar.Global health action · 2017Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore HIV virological failure and drug resistance among injecting drug users (IDUs) receiving first-line antiretroviral treatment (ART) in China.
designA series of cross-sectional surveys from 2003 to 2012 from the Chinese National HIV Drug Resistance (HIVDR) Surveillance and Monitoring Network.
settingChina.
participantsData were analysed by the Chinese National (HIVDR) Surveillance and Monitoring Network from 2003 to 2012. Demographic, ART and laboratory data (CD4+ cell count, viral load and drug resistance) were included. Factors associated with virological failure were identified by logistic regression analysis.
results929 of the 8556 individuals in the Chinese HIVDR database were IDUs receiving first-line ART. For these 929 IDUs, the median duration of treatment was 14 months (IQR 6.0-17.8). 193 of the 929 IDUs (20.8%) experienced virological failure (HIV viral load ≥1000 copies/mL). The prevalence of HIVDR among patients with virological failure was 38.9% (68/175). The proportion of patients with drug resistance to non-nucleoside reverse transcriptase inhibitor (NNRTIs), nucleoside reverse transcriptase inhibitor (NRTIs) and protease inhibitors (PIs) was 52.9%, 76.5% and 4.4%, respectively. Factors independently associated with virological failure include: ethnic minorities, junior high school education or less, farmers, self-reported missing doses in the past month, CD4 cell count at survey from 200 to 349 cells/mm(3) or from 0 to 199 cells/mm(3), and residence of Guangxi and Yunnan provinces.
conclusionsThe proportion of virological failure was high among IDUs receiving first-line ART in China. However, better treatment outcomes were observed in Guangxi and Yunnan, which indicates the importance of ART education and adherence to intervention, especially for patients who are farmers, minorities or have a poor educational background.
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