SynthesisPsychopharmacology2014
Antipsychotic-induced elevation of creatine kinase: a systematic review of the literature and recommendations for the clinical practice.
Synthesis in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Gaps in the detection of drug-drug interactions between antipsychotic and cardiometabolic medications: a multisource analysis.BMC medicine · 2025Pooled it
- Medications Influencing Serum Cystatin C Independent of Measured GFR.Journal of the American Society of Nephrology : JASN · 2026Article
- Paliperidone-Induced Massive Asymptomatic Creatine Kinase Elevation in Youth: From a Case Report to Literature Review.Pediatric reports · 2025Review
- Raised Creatine Kinase with Numerous Antipsychotics Responded to Clozapine.Psychopharmacology bulletin · 2025Article
- The limited clinical utility of a routine creatine kinase (CK) on admission to a psychiatric inpatient unit.BMC psychiatry · 2024Article
- Serum creatine kinase elevation following tyrosine kinase inhibitor treatment in cancer patients: Symptoms, mechanism, and clinical management.Clinical and translational science · 2024Review
- Aripiprazole-induced quasi-neuroleptic malignant syndrome: two case reports.Journal of medical case reports · 2024Article
- Rhabdomyolysis Associated With Mirtazapine and Quetiapine Therapy: A Case Report and Review of the Literature.Cureus · 2024Article
- Evaluation of blood cellular and biochemical parameters in rats under a chronic hypoxic environment at high altitude.Annals of medicine · 2023Article
- Association of the use of psychotropic drugs with hospitalization, cardiovascular events, and mortality in patients with type 2 diabetes: a propensity score-matched cohort study.Frontiers in clinical diabetes and healthcare · 2023Article
- Management of Rhabdomyolysis in a Patient Treated with Clozapine: A Case Report and Clinical Recommendations.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Article
- Case report: Amisulpride therapy induced reversible elevation of creatine kinase-MB and bradycardia in schizophrenia.Frontiers in psychiatry · 2022Article
- Exceptionally high creatine kinase levels in risperidone-induced neuroleptic malignant syndrome: A case report.SAGE open medical case reports · 2022Article
- Article
- A Case of Psychosis and Renal Failure Associated with Excessive Energy Drink Consumption.Case reports in psychiatry · 2019Article
- Comparison of the effects of minimally invasive percutaneous pedicle screws osteosynthesis and open surgery on repairing the pain, inflammation and recovery of thoracolumbar vertebra fracture.Experimental and therapeutic medicine · 2017Article
- Brexpiprazole: so far so good.Therapeutic advances in psychopharmacology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe primary antipsychotic-induced creatine kinase elevation (i.e., not due to neuroleptic malignant syndrome, extrapyramidal symptoms, etc.) is a poorly studied condition.
objectivesThe aims of the present study were to provide an overview of published cases with antipsychotic-induced creatine kinase elevation and give recommendations for the clinical practice.
methodsPubMed and EMBASE were searched for eligible trials, case series, and case reports. We set a threshold at ten times the upper normal limit of the creatine kinase value in order to define an elevation as significant.
resultsThe prevalence of significant creatine kinase elevation ranged between 2 and 7%. We found a total of 42 eligible cases. Men were overrepresented in our sample (81%). Patients with myoglobinuria were more likely to be symptomatic (Fisher's exact test, p = 0.006), whereas neither myoglobinuria (Mann-Whitney test, p > 0.10) nor symptoms (Mann-Whitney test, p = 0.64) were related to the magnitude of the creatine kinase (CK) elevation. In the majority of the cases, the antipsychotic medication was discontinued (86%). Forced diuresis was given in 36% of the patients. Eighty-three percent of the patients had no further complications. Only one case was found with a de novo acute renal failure.
conclusionsThe discontinuation of the antipsychotic medication was a sufficient measure for the CK elevation to subside in the majority of the cases. Cases with myoglobinuria should eventually be treated more aggressively. Further recommendations for the clinical practice are presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.