Evidence map›Paper›PMID 25319707›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014

Manipulating a "cocaine engram" in mice.

Hwa-Lin Liz Hsiang, Jonathan R Epp, Michel C van den Oever, Chen Yan, Asim J Rashid, Nathan Insel, Li Ye, Yosuke Niibori, Karl Deisseroth, Paul W Frankland and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 134 citations in OpenAlex.

  1. Engrams and Memory: My Scientific "Eras Tour".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  7. Spontaneous activity of astrocytes is a stochastic functional signal for memory consolidation.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  13. Comparing behaviours induced by natural memory retrieval and optogenetic reactivation of an engram ensemble in mice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Hwa-Lin Liz HsiangProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada, Institute of Medical Sciences, and Department of Psychology, Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada, and.
Jonathan R EppProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada, Institute of Medical Sciences, and Department of Psychology, Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada, and.
Michel C van den OeverProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada, Institute of Medical Sciences, and Department of Psychology, Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada, and.
Chen YanProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada, Institute of Medical Sciences, and Department of Psychology, Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada, and.
Asim J RashidProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada, Institute of Medical Sciences, and Department of Psychology, Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada, and.
Nathan InselProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada, Institute of Medical Sciences, and Department of Psychology, Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada, and.
Li YeDepartment of Bioengineering and Psychiatry, Stanford University, Stanford, California 94305.
Yosuke NiiboriProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada, Institute of Medical Sciences, and Department of Psychology, Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada, and.
Karl DeisserothDepartment of Bioengineering and Psychiatry, Stanford University, Stanford, California 94305.
Paul W FranklandProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada, Institute of Medical Sciences, and Department of Psychology, Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada, and.
Sheena A JosselynProgram in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada, Institute of Medical Sciences, and Department of Psychology, Physiology, University of Toronto, Toronto, ON, M5G 1X8, Canada, and sheena.josselyn@sickkids.ca.
Institute of Medical Sciences · INHospital for Sick Children · CAStanford University · USUniversity of Toronto · CA

Funding

Canadian Institutes of Health Research MOP-74650Canadian Institutes of Health Research MOP-86762
6 · The paper itself

Abstract

Experience with drugs of abuse (such as cocaine) produces powerful, long-lasting memories that may be important in the development and persistence of drug addiction. The neural mechanisms that mediate how and where these cocaine memories are encoded, consolidated and stored are unknown. Here we used conditioned place preference in mice to examine the precise neural circuits that support the memory of a cocaine-cue association (the "cocaine memory trace" or "cocaine engram"). We found that a small population of neurons (∼10%) in the lateral nucleus of amygdala (LA) were recruited at the time of cocaine-conditioning to become part of this cocaine engram. Neurons with increased levels of the transcription factor CREB were preferentially recruited or allocated to the cocaine engram. Ablating or silencing neurons overexpressing CREB (but not a similar number of random LA neurons) before testing disrupted the expression of a previously acquired cocaine memory, suggesting that neurons overexpressing CREB become a critical hub in what is likely a larger cocaine memory engram. Consistent with theories that coordinated postencoding reactivation of neurons within an engram or cell assembly is crucial for memory consolidation (Marr, 1971; Buzsáki, 1989; Wilson and McNaughton, 1994; McClelland et al., 1995; Girardeau et al., 2009; Dupret et al., 2010; Carr et al., 2011), we also found that post-training suppression, or nondiscriminate activation, of CREB overexpressing neurons impaired consolidation of the cocaine memory. These findings reveal mechanisms underlying how and where drug memories are encoded and stored in the brain and may also inform the development of treatments for drug addiction.

Indexed as

AmygdalaAnimalsCocaineConditioning, PsychologicalCyclic AMP Response Element-Binding ProteinFemaleMaleMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicCocaineCreb1 protein, mouseCyclic AMP Response Element-Binding Proteinamygdalacocaineconditioningmemoryplace preference

Identifiers

PMID25319707
PMCPMC6705287
OpenAlexW2062843325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.