ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
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- Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway.eLife · 2021Article
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- Reoccurring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatiotemporal patterns.PLoS biology · 2020Article
- Conserved and Divergent Features of Adult Neurogenesis in Zebrafish.Frontiers in cell and developmental biology · 2020Review
- Deconstructing Neurogenesis, Transplantation and Genome-Editing as Neural Repair Strategies in Brain Disease.Frontiers in cell and developmental biology · 2020Review
- A non-canonical role for the proneural geneDevelopment (Cambridge, England) · 2018Article
- The neurological toxicity of heavy metals: A fish perspective.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2018Review
- Is Alzheimer's Also a Stem Cell Disease? - The Zebrafish Perspective.Frontiers in cell and developmental biology · 2018Article
- Mechanisms of Pathology-Induced Neural Stem Cell Plasticity and Neural Regeneration in Adult Zebrafish Brain.Current pathobiology reports · 2018Review
- Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish.Developmental biology · 2017Article
- Article
- Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff.Development (Cambridge, England) · 2016Article
- A comparative view of regenerative neurogenesis in vertebrates.Development (Cambridge, England) · 2016Review
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
Balancing quiescence, self-renewal, and differentiation in adult stem cells is critical for tissue homeostasis. The underlying mechanisms, however, remain incompletely understood. Here we identify Fezf2 as a novel regulator of fate balance in adult zebrafish dorsal telencephalic neural stem cells (NSCs). Transgenic reporters show intermingled fezf2-GFP(hi) quiescent and fezf2-GFP(lo) proliferative NSCs. Constitutive or conditional impairment of fezf2 activity demonstrates its requirement for maintaining quiescence. Analyses of genetic chimeras reveal a dose-dependent role of fezf2 in NSC activation, suggesting that the difference in fezf2 levels directionally biases fate. Single NSC profiling coupled with genetic analysis further uncovers a fezf2-dependent gradient Notch activity that is high in quiescent and low in proliferative NSCs. Finally, fezf2-GFP(hi) quiescent and fezf2-GFP(lo) proliferative NSCs are observed in postnatal mouse hippocampus, suggesting possible evolutionary conservation. Our results support a model in which fezf2 heterogeneity patterns gradient Notch activity among neighbors that is critical to balance NSC fate.
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