ArticleRadiation oncology (London, England)2014
GTV-based prescription in SBRT for lung lesions using advanced dose calculation algorithms.
Article in Radiation oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Internal target volume reproducibility and dose coverage for lung stereotactic body radiotherapy using spine-based positioning and tracking.Physics and imaging in radiation oncology · 2026Article
- Internal Target Volume Estimation for Liver Cancer Radiation Therapy Using an Ultra Quality 4-Dimensional Magnetic Resonance Imaging.Advances in radiation oncology · 2025Article
- Harmonization of dose prescription for lung stereotactic radiotherapy.Physics and imaging in radiation oncology · 2022Article
- Validation of Monte Carlo dose calculation algorithm for CyberKnife multileaf collimator.Journal of applied clinical medical physics · 2022Article
- Effectiveness of robust optimization in volumetric modulated arc therapy using 6 and 10 MV flattening filter-free beam therapy planning for lung stereotactic body radiation therapy with a breath-hold technique.Journal of radiation research · 2020Article
- On the pitfalls of PTV in lung SBRT using type-B dose engine: an analysis of PTV and worst case scenario concepts for treatment plan optimization.Radiation oncology (London, England) · 2020Article
- Dose prescription with spatial uncertainty for peripheral lung SBRT.Journal of applied clinical medical physics · 2019Article
- Optimizing the prescription isodose level in stereotactic volumetric-modulated arc radiotherapy of lung lesions as a potential for dose de-escalation.Radiation oncology (London, England) · 2018Article
- Breathing-motion-compensated robotic guided stereotactic body radiation therapy : Patterns of failure analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018Article
- Clinical Results of Mean GTV Dose Optimized Robotic-Guided Stereotactic Body Radiation Therapy for Lung Tumors.Frontiers in oncology · 2018Article
- Time for standardization of SBRT planning through large scale clinical data and guideline-based approaches.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017Article
- Planning benchmark study for SBRT of early stage NSCLC : Results of the DEGRO Working Group Stereotactic Radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2017Article
- Effect of the normalized prescription isodose line on the magnitude of Monte Carlo vs. pencil beam target dose differences for lung stereotactic body radiotherapy.Journal of applied clinical medical physics · 2016Article
- Target dose conversion modeling from pencil beam (PB) to Monte Carlo (MC) for lung SBRT.Radiation oncology (London, England) · 2016Article
- Combination effects of tissue heterogeneity and geometric targeting error in stereotactic body radiotherapy for lung cancer using CyberKnife.Journal of applied clinical medical physics · 2015Article
- Article
- Adapted Prescription Dose for Monte Carlo Algorithm in Lung SBRT: Clinical Outcome on 205 Patients.PloS one · 2015Article
- Dose Prescription Methods in Stereotactic Body Radiotherapy for Small Peripheral Lung Tumors: Approaches Based on the Gross Tumor Volume Are Superior to Prescribing a Dose That Covers 95% of the Planning Target Volume.Technology in cancer research & treatmentArticle
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Abstract
backgroundThe aim of current study was to investigate the way dose is prescribed to lung lesions during SBRT using advanced dose calculation algorithms that take into account electron transport (type B algorithms). As type A algorithms do not take into account secondary electron transport, they overestimate the dose to lung lesions. Type B algorithms are more accurate but still no consensus is reached regarding dose prescription. The positive clinical results obtained using type A algorithms should be used as a starting point.
methodsIn current work a dose-calculation experiment is performed, presenting different prescription methods. Three cases with three different sizes of peripheral lung lesions were planned using three different treatment platforms. For each individual case 60 Gy to the PTV was prescribed using a type A algorithm and the dose distribution was recalculated using a type B algorithm in order to evaluate the impact of the secondary electron transport. Secondly, for each case a type B algorithm was used to prescribe 48 Gy to the PTV, and the resulting doses to the GTV were analyzed. Finally, prescriptions based on specific GTV dose volumes were evaluated.
resultsWhen using a type A algorithm to prescribe the same dose to the PTV, the differences regarding median GTV doses among platforms and cases were always less than 10% of the prescription dose. The prescription to the PTV based on type B algorithms, leads to a more important variability of the median GTV dose among cases and among platforms, (respectively 24%, and 28%). However, when 54 Gy was prescribed as median GTV dose, using a type B algorithm, the variability observed was minimal.
conclusionNormalizing the prescription dose to the median GTV dose for lung lesions avoids variability among different cases and treatment platforms of SBRT when type B algorithms are used to calculate the dose. The combination of using a type A algorithm to optimize a homogeneous dose in the PTV and using a type B algorithm to prescribe the median GTV dose provides a very robust method for treating lung lesions.
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