Evidence map›Paper›PMID 25319433›Full record

ArticleAngewandte Chemie (International ed. in English)2014

Differential sensing of MAP kinases using SOX-peptides.

Diana Zamora-Olivares, Tamer S Kaoud, Jiney Jose, Andrew Ellington, Kevin N Dalby, Eric V Anslyn

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
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  3. Article
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  13. Array-based "Chemical Nose" Sensing in Diagnostics and Drug Discovery.Angewandte Chemie (International ed. in English) · 2019
    Review
  14. Article
  15. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Diana Zamora-OlivaresDepartment of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A1590, Austin, Texas 78712 (USA).
Tamer S Kaoud
Jiney Jose
Andrew Ellington
Kevin N Dalby
Eric V Anslyn

Funding

Mechanism and Specificity of MAP KinasesR01GM059802 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI DALBY, KEVIN N · 2001 to 2011
$2.3M
Novel Therapeutics for Translation Control in Breast CancerR21CA167505 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI DALBY, KEVIN N, OZPOLAT, BULENT · 2012 to 2013
$369k
NCI NIH HHS CA167505NCI NIH HHS R21 CA167505NIGMS NIH HHS GM059802NIGMS NIH HHS R01 GM059802
6 · The paper itself

Abstract

Five SOX peptides are used to classify the MAPK groups and isoforms thereof using chemometrics. The score plots show excellent classification and accuracy, while support vector machine analysis leads to the quantification of ERK and an ERK inhibitor concentration in kinase mixtures. Examination of the loading plots reveals cross-reactivity among the peptides, and some unexpected surprises.

Indexed as

Mitogen-Activated Protein KinasesMolecular StructurePeptidesSulfonamidesMitogen-Activated Protein KinasesPeptidesSulfonamidesbiosensorschemometricsdifferential sensingfluorescent probesmitogen-activated protein kinases

Identifiers

PMID25319433
PMCPMC13292785

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.