ReviewImmunological reviews2014
Epigenomics of macrophages.
Review in Immunological reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- The response to kidney injury is epigenetically regulated through the activation of bivalent genes.American journal of physiology. Renal physiology · 2026Article
- Article
- Regenerative inflammation: When immune cells help to re-build tissues.The FEBS journal · 2024Review
- Turning foes into permissive hosts: manipulation of macrophage polarization by intracellular bacteria.Current opinion in immunology · 2023Review
- Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?Immunological reviews · 2023Review
- Stimulation of the farnesoid X receptor promotes M2 macrophage polarization.Frontiers in immunology · 2023Article
- Transcriptional and Immune Landscape of Cardiac Sarcoidosis.Circulation research · 2022Article
- Enhancer RNA: What we know and what we can achieve.Cell proliferation · 2022Review
- Multifunctional exosomes derived from bone marrow stem cells for fulfilled osseointegration.Frontiers in chemistry · 2022Review
- Transcriptional repression shapes the identity and function of tissue macrophages.FEBS open bio · 2021Review
- ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization.Nature communications · 2021Article
- Cell-specific epigenetic changes in atherosclerosis.Clinical science (London, England : 1979) · 2021Review
- Response to Oxidative Burst-Induced Hypoxia Is Associated With Macrophage Inflammatory Profiles as Revealed by Cellular Genome-Wide Association.Frontiers in immunology · 2021Article
- Regulation of inflammation in diabetes: From genetics to epigenomics evidence.Molecular metabolism · 2020Review
- Long Non-coding RNAs RN7SK and GAS5 Regulate Macrophage Polarization and Innate Immune Responses.Frontiers in immunology · 2020Article
- Unorthodox Transcriptional Mechanisms of Lipid-Sensing Nuclear Receptors in Macrophages: Are We Opening a New Chapter?Frontiers in endocrinology · 2020Review
- Epigenetic Mechanisms in Monocytes/Macrophages Regulate Inflammation in Cardiometabolic and Vascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2019Review
- Nature and nurture of tissue-specific macrophage phenotypes.Atherosclerosis · 2019Review
- Epigenetics for the 21st-Century Biology Student.Journal of microbiology & biology education · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Macrophages play essential roles in tissue homeostasis, pathogen elimination, and tissue repair. A defining characteristic of these cells is their ability to efficiently adapt to a variety of abruptly changing and complex environments. This ability is intrinsically linked to a capacity to quickly alter their transcriptome, and this is tightly associated with the epigenomic organization of these cells and, in particular, their enhancer repertoire. Indeed, enhancers are genomic sites that serve as platforms for the integration of signaling pathways with the mechanisms that regulate mRNA transcription. Notably, transcription is pervasive at active enhancers and enhancer RNAs (eRNAs) are tightly coupled to regulated transcription of protein-coding genes. Furthermore, given that each cell type possesses a defining enhancer repertoire, studies on enhancers provide a powerful method to study how specialization of functions among the diverse macrophage subtypes may arise. Here, we review recent studies providing insights into the distinct mechanisms that contribute to the establishment of enhancers and their role in the regulation of transcription in macrophages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.