Evidence map›Paper›PMID 25319325›Full record

ReviewImmunological reviews2014

Origin, development, and homeostasis of tissue-resident macrophages.

Malay Haldar, Kenneth M Murphy

Abstract readReview
In one paragraph

Review in Immunological reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Macrophages in Hematopoiesis and Related Blood Diseases.Genomics, proteomics & bioinformatics · 2025
    Review
  7. A mixture of organophosphate esters sex-specifically impacts monocyte-macrophages in Sprague-Dawley rats.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  8. Exploring CD169Vaccines · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Pathophysiology of Inflammatory Bowel Disease: Innate Immune System.International journal of molecular sciences · 2023
    Review
  15. Review
  16. Review
  17. Review
  18. An Eye on Kupffer Cells: Development, Phenotype and the Macrophage Niche.International journal of molecular sciences · 2022
    Review
  19. Article
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Malay HaldarDepartment of Pathology and Immunology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Kenneth M Murphy

Funding

TRAINING IN THE IMMUNOBIOLOGY AND MOLECULAR CELL BIOLOGY OF CANCERT32CA009547 · NCI · WASHINGTON UNIVERSITY · PI ROBERT DAVID SCHREIBER · 1986 to 2026
$12.1M
METABOLIC CONTROL OF TISSUE SPECIFIC MACROPHAGE DIFFERENTIATIONK08AI106953 · NIAID · WASHINGTON UNIVERSITY · PI HALDAR, MALAY · 2013 to 2017
$857k
Howard Hughes Medical InstituteNCI NIH HHS T32 CA009547NCI NIH HHS T32 CA9547-27NIAID NIH HHS K08 AI106953NIAID NIH HHS K08AI106953
6 · The paper itself

Abstract

Macrophages are versatile cells of the hematopoietic system that display remarkable functional diversity encompassing innate immune responses, tissue development, and tissue homeostasis. Macrophages are present in almost all tissues of the body and display distinct location-specific phenotypes and gene expression profiles. Recent studies also demonstrate distinct origins of tissue-resident macrophages. This emerging picture of ontological, functional, and phenotypic heterogeneity within tissue macrophages has altered our understanding of these cells, which play important roles in many human diseases. In this review, we discuss the different origins of tissue macrophages, the transcription factors regulating their development, and the mechanisms underlying their homeostasis at steady state.

Indexed as

HomeostasisAnimalsCell DifferentiationHumansMacrophagesOrgan Specificitycell differentiationimmune system ontogenylineage commitmentmonocytes/macrophages

Identifiers

PMID25319325
PMCPMC4203404

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.