ArticleJournal of mathematical biology2015
Stochastic control of proliferation and differentiation in stem cell dynamics.
Article in Journal of mathematical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Mathematical modelling identifies conditions for maintaining and escaping feedback control in the intestinal epithelium.Scientific reports · 2022Article
- A General Theoretical Framework to Study the Influence of Electrical Fields on Mesenchymal Stem Cells.Frontiers in bioengineering and biotechnology · 2020Article
- Effect of cellular de-differentiation on the dynamics and evolution of tissue and tumor cells in mathematical models with feedback regulation.Journal of theoretical biology · 2018Article
- Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy.Cancer research · 2017Article
- Feedback control in planarian stem cell systems.BMC systems biology · 2016Article
- Overshoot during phenotypic switching of cancer cell populations.Scientific reports · 2015Article
- Analysis of stochastic stem cell models with control.Mathematical biosciences · 2015Article
- Principles of regulation of self-renewing cell lineages.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In self-renewing tissues, cell lineages consisting of stem cell and classes of daughter cells are the basic units which are responsible for the correct functioning of the organ. Cell proliferation and differentiation in lineages is thought to be mediated by feedback signals. In the simplest case a lineage is comprised of stem cells and differentiated cells. We create a model where stem cell proliferation and differentiation are controlled by the size of cell populations by means of a negative feedback loop. This two-dimensional Markov process allows for an analytical solution for the mean numbers and variances of stem and daughter cells. The mean values and the amounts of variation in cell numbers can be tightly regulated by the parameters of the control loop.
Indexed as
Identifiers
25319118What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.